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Prediction of drug-induced nephrotoxicity and injury mechanisms with human induced pluripotent stem cell-derived cells and machine learning methods. Furthermore, hyperoxia induced a significant tumor growth-inhibitory effect, with significant down-regulation of the MAPK pathway. The results show that BmP02 formed a alpha/beta scorpion fold, the typical three-dimensional structure adopted by most short chain scorpion toxins whose structures have been determined.

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Opioid modulation of LHRH release in vitro depends upon levels of testosterone in vivo. Our results support the functional role of pfmdr1 as a transport molecule in the mediation of drug resistance and provide an assay system to address the nature of this transport function. With further understanding of the mechanisms by which these compounds exert these effects, we can anticipate that new and more active compounds will be developed and that further activities of existing compounds will be found. Interaction of beta-endorphin, naloxone and dopamine: effects on melanocyte-stimulating hormone secretion of amphibian pituitaries in vitro. The 2006 Early Detection and Screening for Prostate Cancer Knowledge, Attitudes and Practice Survey conducted by the Michigan Public Health Institute investigated the beliefs and practice patterns of primary care providers in Michigan.

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Gene therapy by delivery of nonviral expression vectors is highly desirable, due to their safety, stability, and suitability for production as bulk pharmaceuticals. Molecular cloning and genetic analysis of the suppressor-of-white-apricot locus from Drosophila melanogaster. To study the effect of intron size on splicing efficiency we have varied the size of the avian leukosis virus (ALV) env mRNA intron in a cloned ALV genome.

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Successful prevention of IPD and resultant preterm delivery could substantially improve neonatal and maternal outcomes. In response to emetine, we found a strong reduction in viability, an induction of apoptosis and caspase activity comparable to the cytotoxic effect of cisplatin. Interestingly, some of the phenotypic consequences of these mutations resemble human diseases, such as diabetic retinopathy. Major barriers separating the blood from tissue compartments in the body are composed of endothelial cells.

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This result may due to the increase of gene dispersal compensating the effect of the disturbance as suggested by the reduced extent of SGS estimated in this population. Three different techniques, namely direct spreading, glass cover-slip, and indented coupon were compared to determine the photocatalytic bactericidal property of TiO2 coatings against Escherichia coli 0157:H7 at 2 mW/cm(2) UVA light intensity. The F7 gene and clotting factor VII levels: dissection of a human quantitative trait locus. Forty-five percent presented type II defects, where bilateral mastopexy was performed in 52 percent.

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Lymphocytes were transduced with TRAIL lentivirus and the antitumor effect in presence and absence of EpCAMxCD3 was evaluated in vitro and in xenograft studies using epithelial cell adhesion molecule (EpCAM)-positive pancreatic and prostate cancer cells. Antibody responses were mainly found in melanoma patients and all tested antigens elicited immune responses in all disease stages.

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To assess the efficacy of the superior hypogastric nerve block (SHNB) in permitting uterine artery embolization (UAE) to be performed as a routine outpatient procedure. Chest pain is a common reason for referral to pediatric cardiologists and often leads to an extensive cardiac evaluation.

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We believe this is the first report of a case of presumed bilateral, geographic, peripapillary chorioretinal atrophy in a patient with PCT, complicated by high iron stores, HCV, and alcoholism. The aim of this paper is to review the most innovative and relevant aspects of lung pathology in patients infected with HIV. Carbetocin is associated with a reduced use of additional oxytocics. 395 diabetic patients registered with four general practices in an inner city location.

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This study provides quantitative data on the extent of gyrencephaly in the large-brained African elephant and several species of cetaceans (from smaller to larger brained) in comparison with other mammals. The new method is applied to the quantification of membrane-bound immunoglobulin molecules of the IgG-type on single human lymphocytes. All subjects were healthy, without cardiovascular risk factors, and had no prior exposure to acceleration forces.

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Thermochemical treatment of sewage sludge ash with sodium salt additives for phosphorus fertilizer production--Analysis of underlying chemical reactions. The nature of glass phases of liquid crystals in random porous media depends on the effective disorder strength.

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Several more years had to pass before it was accepted that this receptor plays the key role in the action mechanism of buspirone. We suspect it may have originated from thyroglossal duct structures. Converting inner retinal neurons to photosensitive cells by expressing channelrhodopsin-2 (ChR2) offers a novel approach for treating blindness caused by retinal degenerative diseases. For the achromatic pattern reversal stimulation, a double slope function describes how the P100 amplitude varied as a function of log contrast which had a limb at low-to-medium contrasts and another limb at high contrasts. To determine the effect of central corneal thickness (CCT) on the efficacy of intraocular pressure (IOP)-reducing drugs in patients with ocular hypertension (OHT).

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Our data indicate that several aspects of myocardial hypertrophy are accelerated by smoking. The binding of urinary conjugated steroids to serum albumin: a new method of extraction. However, limited functionality of nanodevices used in CMOL circuits causes significant challenges to train CrossNets with the usual algorithms. When uncontrolled, peripheral blood eosinophilia may result in end-organ damage and life-threatening complications. Early postnatal diazepam exposure facilitates maternal behavior in virgin female rats.

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The objective of this pilot study was to investigate the effect of Healing Touch on state/trait anxiety and physiological measures of heart rate, blood pressure, muscle tension, skin conductance, and skin temperature in healthy adults. A 76-year-old woman underwent L3-S1 laminectomies and fusion for lumbar spondylosis and stenosis. Design of optimal noise hazard control strategy with budget constraint. Overexpression of mitogen-activated protein kinase (MAPK) kinase kinase (MEKK-1), which preferentially activates JNK, mimics, in a nonadditive way, hypoxia-induced activity of the MDR1 promoter and expression of MDR1 mRNA and P-glycoprotein.

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The purpose of this report is to describe a case involving severe anemia in a patient from New Caledonia. Evidence that the secretory apparatus in the thymus of mice is not aberrant thyroid tissue. This study aims to evaluate the clinical characteristics and immunological phenotype of shellfish allergy in this population.

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Many reporter genes, such as gfp, gusA, and lacZ, are widely used for research into plants, animals, and microorganisms. This information when combined with the orthopedic and medical components of a preparticipation examination can dramatically enhance the safety of sports participation. VM-26 plus CCNU in the prevention of brain metastasis in lung cancer patients

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Here, we related EEG alpha rhythm in awake humans to blood-oxygen-level-dependent (BOLD) signal change determined by functional magnetic resonance imaging (fMRI). Regions of the internal transcribed spacer (ITS2) from 60 samples were sequenced, and new primers for cattail pollen were designed according to the sequence information. The gene encoding D-amino acid oxidase (DAO), which acts as a receptor for the schizophrenia-associated neurotransmitter, N-methyl-D-aspartate (NMDA), is regarded as a potential candidate gene for schizophrenia.

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Equine sarcoids represent the most common skin tumours in equids worldwide, characterized by extensive invasion and infiltration of lymphatics, rare regression and high recurrence after surgical intervention. We investigated the elemental composition of the fumble mutant, a model of the human disease. Studies in marine organisms, in particular echinoderms, have been limited by the lack of well-described cellular culture systems. This study reviews LC during pregnancy in my series and compares this experience with the published literature.

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