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Epivir (Lamivudine)

Epivir is a pyrimidine analog reverse transcriptase enzyme inhibitor active against human immunodeficiency virus type I (HIV1), HIV2, Hepatitis B virus, in vitro and in vivo. Intracellularly it is metabolized to its active triphosphate form by multiple kinases. The triphosphate form competes with deoxycytidine triphosphate for binding to reverse transcriptase, and the incorporation of this 3TC-triphosphate (3TC-TP) form in viral DNA results in chain termination. It is FDA approved for treatment of HIV infections in children and adults in a three drug regimen along with other nucleoside analogs, protease inhibitors and non-nucleoside reverse transcriptase inhibitors.

Other names for this medication:
Lamivudine, Epivir, Heptovir, Lamivudina, Lamzid, Zeffix,

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Hypothalamic-pituitary-adrenocortical axis function in attention-deficit hyperactivity disorder. Neuromuscular response of the trunk to inertial based sudden perturbations following whole body vibration exposure.

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Demonstration of human kidney differentiation antigens with monoclonal antibodies. Fatty acid acylation (principally of gE) could be detected just prior to the shifts, whereas conversion of high-mannose-type N-linked oligosaccharides to the complex type occurred coincident with the shifts. Against the backdrop of this language, the author reflects on the lived experience of lesbian clients who have come to therapy for relationship violence. Apropos of a case of tracheobronchial resection for a cylindroma Economic burden of obesity and its comorbidities in Switzerland.

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The method is based on an analysis of the histogram curve, the proportion of area and thickness of the liquor spaces being related to the total area below the curve. Tethered bilayer lipid membranes (tBLM) offer a promising means to immobilize membrane proteins for sensor applications and study biological phenomena including membrane-nanoparticle interactions. Autoimmune progesterone dermatitis is a rare cutaneous disorder characterized by recurrent and cyclic skin eruption with variable morphology, occurring during the luteal phase.

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Rupture of a vulvar varix with massive and extensive hemorrhage following a normal delivery. This impedance can be spatially modulated by locally changing the size/orientation of the texture elements. High-performance activity with below-knee cast treatment, part I: mechanics and demonstration. Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study. Here, we present the first evidence of the involvement of individual serotonin receptors in olfactory learning and memory in the fly.

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High-throughput methods permit genome-wide searches to discover genes that are uniquely expressed in brain circuits and regions that control behavior. The thrombolytic properties of a new variant of tissue plasminogen activator (TPA) (T103N, N117Q, KHRR 296-299 AAAA, or TNK-TPA) with longer plasma half-life, greater fibrin specificity, and increased resistance to inhibition by plasminogen activator inhibitor (PAI-1) were investigated in a rabbit thrombosed carotid artery model.

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Only a few attempts, however, have been made to estimate the heritability of parental behaviours and their possible co-evolution with offspring solicitation behaviour. X-ray diagnosis of fibrosis in destructive forms of pulmonary tuberculosis Both chronic hyperglycemia and ischemia/reperfusion (IR) cause an imbalance in the oxidative state of tissues. Synthesis of novel N-diazeniumdiolates based on hyperbranched polyethers.

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Three patients tested against their autologous tumor and normal lung extracts were specifically inhibited by the tumor extract (average MI equals 0.53) but not by the normal lung extract (average MI equals 0.83). ETHE1 encodes for a mitochondrial enzyme involved in sulfide detoxification and TYMP for a cytosolic enzyme involved in the thymidine/deoxyuridine catabolic pathway. Resinous denture base fracture resistance: effects of thickness and teeth. Ovarian teratoma with predominant hemangiomatous component in early childhood.

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Effect of work environment in aluminum foundries at Skawini on the periodontium and oral mucosa Monoclonal antibodies against baboon endogenous virus and against host cell antigens. These results suggest that particle size due to grinding is more important than other methods of processing.

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Effect of post-thaw addition of seminal plasma on motility, viability and chromatin integrity of cryopreserved donkey jack (Equus asinus) spermatozoa. Our study also showed that the intrinsic life cycle of erythrocytic P. On possible primary selection of antitumor antibiotics according to their effect on the growth of a biochemical mutant of Staph.

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Fully investigated patient had some reversible changes in the urinary tract. The fracture may not be visible on radiographs obtained near the onset of symptoms, and serial examinations may be needed for diagnosis. Vagal afferent-dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA-NR2B receptors in rats. In addition, a transcriptome-wide search for polymorphic loci yielded a total of 11,228 simple sequence repeats (SSRs) from 9,938 unigenes and 138,631 single nucleotide polymorphism (SNP) and insertion/deletion (INDEL) sites among 22,770 unigenes. Re-expression of PTEN induced strong apoptosis and growth inhibition.

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Information needed to support hazard identification and risk assessment of toxic substances. Reaction mechanisms of indole-3-acetate degradation by peroxidases. Posttraumatic stress symptoms and health-related quality of life: a two year follow up study of injury treated at the emergency department. To evaluate the safety profile of platelet glycoprotein IIb/IIIa inhibitors administered as adjunctive therapy to patients with large-vessel occlusion and acute ischemic stroke refractory to pharmacological thrombolysis with recombinant tissue plasminogen activator (rtPA) and mechanical disruption, balloon angioplasty, or both. To compare the different serum peptidome patterns between twins with and without non-alcoholic fatty liver disease (NAFLD) in order to help understand the pathogenesis of NAFLD and to identify potential diagnostic and therapeutic targets.

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Acute effects of alcohol on P300 in Asians with different ALDH2 genotypes. Noradrenaline (10(-5) M) application evoked an increase of EPSP amplitude, accompanied by an increase of the input resistance.

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Prior to the experiment, they viewed pictures of paintings and listened to musical excerpts, both of which they rated on a scale of 1-9, with 9 being the most beautiful. To identify stress and stress-relieving mechanisms among second-year pharmacy students in a 3-year doctor of pharmacy (PharmD) program using a Mastery Learning Educational Model and to compare findings with those from a 4-year program. Little evidence exists about optimal caries-prevention strategies during orthodontic treatment.

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It is shown that in subacute encephalomyelitis, similar processes develop. Teaching Quality Improvement in Graduate Medical Education: An Experiential and Team-Based Approach to the Acquisition of Quality Improvement Competencies. The temporal course of the antibody response was similar to those reported in adults while anti-EA-D and heterophil antibodies were demonstrated less frequently.

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After E2 therapy for 7 days, HT GnRH content and PT GnRH receptor sites returned to normal levels in all age groups. Biphasic anti-osteoclastic action of intravenous alendronate therapy in multiple myeloma bone disease. Analyses of infections with serotypes Ad4 and Ad12 demonstrated that the degradation of Mre11/Rad50/Nbs1 proteins is a conserved feature of the E1b55K/E4orf6 complex.

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Here we show evidence for PIN1 gene deletion and mRNA under-expression as a mechanism of Pin1 reduction in ccRCC tumors. Unusual metastases from a transitional-cell carcinoma of the renal pelvis and ureter. Zoonoses research in the German National Cohort : feasibility of parallel sampling of pets and owners.

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We report a case of isolated CIAI from blunt trauma without bony injury treated successfully using endovascular repair. Establishment of reentry intervals for organophosphate-treated cotton is gabapentin good for restless leg syndrome fields based on human data. Decreased Serum Levels of S-100B Protein Reflect Successful Treatment Effects in a Rabbit Model of Acute Ischemic Stroke. The investigation of pituitary reserve requires knowledge of the risk factors for the development of hypopituitarism and thus biochemical testing is underpinned by the need for a meticulously taken medical history and careful examination of the patient. These results may be explained by the lower enzymatic activity associated with the Lys(27)Lys CDA and offer a potential new tool for treatment optimization.

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