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Area normalization of the renal region of interest in radionuclide renography data analysis: a misconception. Consequently overproduction of local estrogen may promote carcinogenesis or proliferation of breast cancer cells. Carrier and prenatal diagnostic strategy and newly identified mutations in Hungarian haemophilia A and B families.

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There is no consensus on the optimal treatment for localized high-risk prostate cancer (PC), and much debate exists regarding the ideal treatment approach. These studies indicate that physiological concentrations of CLA inhibit growth of colon cancer cells with either wild-type or mutant p53, and may have therapeutic benefits in vivo.

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Interaction of amphetamine and its N-alkyl-substituted derivatives with micro- and mesoporous adsorbents in polar liquids. The scan was extended up to foot in view of the fact that a prior bone scan had shown a focal uptake in the similar location. In other experiments, low-sodium perfusion was used to manipulate sodium-calcium exchange in the presence and absence of P1Pi. Mutational analysis of the HIS4 translational initiator region in Saccharomyces cerevisiae.

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SELECTION OF KOCH BACILLI GENETICALLY RESISTANT TO ISONIAZID AND STREPTOMYCIN. These results suggest that TNF-alpha enhances in vitro vascular calcification by promoting osteoblastic differentiation of vascular cells through the cAMP pathway.

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Here, we have synthesized and characterized low MW compounds modulating myogenic differentiation via induction of TAZ nuclear localization. Our clinical observation that the kidney size and volume of pediatric patients, determined by ultrasound, differ significantly from the standard value schedules (Weitzel) in general use led us to reevaluate the size and volume of normal kidneys in infancy and childhood sonographically. Plasma glucose was slightly elevated in pentobarbital-anesthetized obese rats. Peripheral facilitation of reflex vasoconstriction by prostaglandin F2alpha.

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Among the top 10 diseases identified by this review, the majority were zoonoses. A winged-helix protein from Sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus. Two-dimensional correlation spectroscopy also can differentiate the turn structure of Ab42 and other Ab derivatives. Comparing Doppler ultrasonography and cerebral oximetry as indicators for shunting in carotid endarterectomy. Large pelvic varicosities may be present in women with congenital heart disease.

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Earlier studies have shown that patients suffering from juvenile arthritis (JA) have reduced serum concentrations of antioxidants compared with healthy controls. WGEP analysis revealed that not all cAMP activation is the same: adrenal lesions harboring PRKAR1A or GNAS mutations share the downstream activation of certain oncogenic signals (such as MAPK and some cell cycle genes) but differ substantially in their effects on others. Identification of the essential regions for inhibitory functions shown by the DNA segment containing the replication origin. Plasma levels of methotrexate in cancer patients as studied by an improved spectrophotofluorometric method.

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Influenza virus and the beginnings of its study in the laboratory. Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium.

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Coupling between neuronal firing rate, gamma LFP, and BOLD fMRI is related to interneuronal correlations. The static force platform assessment demonstrated a worsening of the balance independent from the visual control with the use of 400-g and 800-g implants. Sham operation was carried out in group 2 and the 3rd group served as control. Incubation of PMN-SF mixtures with collagen fibrils precoated with monomeric IgG resulted in significant lysis of the underlying fibrils relative to that seen with uncoated fibrils. Animals housed with running wheels and subjected to daily food restriction show paradoxical reductions in food intake and increases in running wheel activity.

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The text presents application of fractal geometry (fractal dimension) for complex surface analysis in combination with standard roughness parameters (statistical tool). Uridine diphosphoglucuronate-glucuronosyltransferase 1A1 (UGT1A1) gene mutation was shown to be responsible for neonatal hyperbilirubinemia. The oriented limited axillary dissection technique, combined with frozen section histological examination, avoids the usually unnecessary secondary operations in small breast cancers, in which axillary lymph node invasion rarely exceeds more than two nodes. Repeated acute ozone exposure has more additive effect on peripheral leukocyte counts in active animals.

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The primary goal in the rheumatoid shoulder is a pain-free joint with a functional range of motion. Targeting dyslipidemia with rosuvastatin was associated with more favorable changes in the LDL subfraction profile in patients with IFG compared to normoglycemic ones.

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After introduction of the standard mastitis prevention programme, all quarters of infected cows were treated during lactation. Stimulation of the maxillary tooth pulp nerve (TP), a predominantly nociceptive afferent fiber system, was assessed for its effect on peripheral plasma ACTH in chloralose-urethane anesthetized cats. ASSOCIATION OF DIARRHEA WITH GIARDIA LAMBLIA IN FAMILIES OBSERVED WEEKLY FOR OCCURRENCE OF ENTERIC INFECTIONS. We have now examined whether the E2 activity of RAD6 is involved in its various biological functions. However, STAT4 or IFN-gamma deficiency resulted in significantly increased viral replication and significantly reduced TNF-alpha and IFN-gamma levels in the heart, similar to IL-12 deficiency, indicating that the IL-12/STAT4 pathway of IFN-gamma production is important in limiting CVB3 replication.

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Granuloma from talc and sulfamide powders in the peritoneal cavity Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. This field study showed that offshore fleet workers are able to adapt to the imposed regimen of 12-h night shifts.

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A caspase activity assay revealed the sequential activation of caspases 8, 3 and 6, and caspases 9, 3 and 6, respectively. Ruthenium-catalyzed oxidative C-H bond olefination of N-methoxybenzamides using an oxidizing directing group with a broad substrate scope is reported. Overwhelming lines of epidemiological evidence have indicated that persistent infection with hepatitis C virus (HCV) is a major risk for the development of hepatocellular carcinoma (HCC).

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Vacuum apparatus for functional occlusion method of full dental prosthesis Results indicate that it has high test-retest reliability and internal consistency. Paclitaxel via oxygen radical formation targets TRPA1 and TRPV4, and both channels are key for the delayed development of mechanical allodynia. Spastic threshold velocity correlated with limitations in joint angular velocity during walking and functional performance. Information about the effect of pirmenol on the fast sodium current was obtained by Vmax-measurement.

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Our study indicated that the presence of pleuritic chest pain and pleural effusion had a favourable effect on the outcome. Between November 2008 and October 2009, we conducted a prospective cohort study of women obtaining medical abortion by telemedicine or face-to-face physician visits. Paternal height, parity, maternal pregravid weight and gestational weight gain were strongly associated with LGA infants. External hemorrhoids also bleed and can cause acute pain if thrombosed.

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The identification of genetic mutations in chylomicron retention disease indicates that Sar1b may play a critical role in this process. Possible role of citrate synthase in conferring multistress-tolerance was postulated. Investigation of genetic variants of genes of the hemochromatosis pathway and their role in breast cancer.

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No correlation was found between presence or extent of labral lesions and any radiographic parameter tested, except osteoarthritis classification. The network analysis shows that the phase spaces of systems with different boundary conditions share some common features. Kinetics and proliferative activity of stem hematopoietic cells in organ cultures of intact and rapidly proliferating bone marrow in adult mice Both conditions also reported several significant improvements on several clinical outcomes over time.

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Biodistribution and general safety of a naked DNA plasmid, GTU-MultiHIV, in a rat, using a quantitative PCR method. Responses to GABA by isolated insect neuronal somata: pharmacology and modulation by a benzodiazepine and a barbiturate.

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Geometric distortion in clinical MRI systems Part II: correction using a 3D phantom. Preimplantation genetic diagnosis for beta-thalassaemia: the Sardinian experience. The unusually rapid decline in symptoms, accompanied by uniform sleep parameter changes toward markedly increased regularity, suggest that blue-blockers might be targeting a central mechanism in the pathophysiology of mania that needs to be explored both in clinical research and in basic science. Improvement in left ventricular function and oxygenation index after vasopressin initiation was associated with a decreased need for extracorporeal membrane oxygenation therapy.

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We describe our experience regarding a case of a manifest left anterior accessory pathway ablation using radiofrequency energy at the junction of the left coronary cusp with the non-coronary cusp. Prior to treatment, optimism, social support, and well-being had been assessed. Pressure-induced ferromagnetism in (In,Mn)Sb dilute magnetic semiconductor. Our findings indicate that repression of p66Shc expression by SIRT1 contributes to the protection of hyperglycemia-induced endothelial dysfunction.

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In the dynamic assessment of digital vascular perfusion, LSCI correlates well with IRT, is reproducible and responsive to reduction in ambient room temperature. The authors outline an a priori model relating clinical and informatics competencies.

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The skills and techniques developed by outstanding surgeons like Astley Cooper of the 19th century have withstood the test of time and have been refined by subsequent generations of surgical masters. This secretion is profoundly altered by interleukin-1 alpha (IL-1 alpha). The analysis included plant fibre content in four groups of products considered as the main source of fibre in diet: cereals, potatoes, vegetables and fruit.

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The sequence was derived from peptides obtained by digestion of the apoprotein with trypsin and chymotrypsin, and by subdigestion of some of the peptides with Staphylococcus aureus protease and thermolysin. Proceedings: The concentration ratio of tissue to medium of mono- and polymers in isolated guinea pig atria. Inhibition of ACE2 and arginase I was reached only at concentrations three orders of magnitude greater. In addition to displaying sufficiently different resonance frequencies of their mobile protons, it is also important that the CEST agents designed for this application are highly sensitive.

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This 70-year-old woman, with a history of chronic occlusion of the left internal carotid artery, recovered fully, without evidence of neurologic or myocardial insult. Prevention of recurrent bleeding from gastric ulcer with a nonbleeding visible vessel by endoscopic injection of absolute ethanol: a prospective, controlled trial. Electrosurgical loop excision of the cervical transformation zone and ELECTZ conization may be safely and effectively performed in office settings by family physicians. Therefore, it would be necessary to have a tool to non-invasively monitor the efficacy of such novel therapies.

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The objective was to determine whether daily supplementation of HIV-unexposed Tanzanian infants with MVs or zinc reduces the risk of infectious morbidity compared with placebo. To evaluate the effectiveness and safety of holmium laser enucleation of the prostate (HoLEP) and transurethral resection of the prostate (TURP)/open prostatectomy (OP) in the treatment of bladder outlet obstruction (BOO) secondary to benign prostatic hyperplasia (BPH).

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The objective of this study was to identify causes of errors during a simulated, prehospital pediatric emergency. Thermal properties of the crystals were investigated using thermo gravimetric (TG) and differential thermal analyses (DTA). Home telehealth: patient satisfaction, program functions, and challenges for the care coordinator.

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Six affected aborted or stillborn calves were homozygous for the recently characterized deletion mutation in SLC4A2. Hence, our results suggest that pest resistance mediated by the alteration of a shared Cry receptor binding site might render all three Cry toxins ineffective. Further studies on the action of chlorpropamide in diabetes mellitus. In vivo experiment, in which ACTH was injected s.c., indicated that the response of serum PRG was slightly earlier than the CB response and peaked with a subsequent decline in immature rats.

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In addition, the results also indicated that upregulation of miR-95 could significantly enhance the susceptibilities of NSCLC cells to chemo- or radiotherapy. The remineralization process illustrated a complex interplay between surface and subsurface mineral deposition, confining the thermal-wave centroid toward the dominating layer. There was no enhancement of the response when zymosan was used for stimulation of the cells. High-SES schools sold more healthy items than low-SES schools regardless of state laws. Occlusion of subclavian-innominate veins: the increasing problem of receiving improper care.

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Between 26 September 1995-29 February 1996, six parasite-free bull calves were individually inoculated with 15 to 50 infective third stage larvae (L3)/kg of body weight cultured from adult D. Cbx-rs2 (M31), a mouse homolog of the Drosophila Heterochromatin protein 1 gene, maps to distal chromosome 11 and is nonallelic to Om. An in-vitro study of the effect of buffer on the degradation of poly(glycolic acid) sutures. The potential role of BM MSCs in IPF is another interesting field for further investigation.

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Primary structure of the receptor for calcium channel blockers from skeletal muscle. of 44, 42, and 41 kDa were predominant among the LPS-induced tyrosine phosphoproteins, and they were identified as mitogen-activated protein kinase isoforms ERK1, ERK2, and p38, respectively. In this report, we have tested the hypothesis that the combination of these two interventions, general physical activity and antidepressant treatment, leads to increased levels of specific promoter-derived transcripts of brain-derived neurotrophic factor messenger RNA in a manner that appears to be both additive and accelerated.

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Falciparum malaria presenting as testicular pain and swelling--a rejoinder. The mucin phenotype was determined immunohistochemically using markers for M1, apomucin (MUC) 6 and MUC2. The effects of beta-endorphin, morphiceptin, and delta-receptor peptide were reversed with naloxone, although naloxone alone had no effect on lordosis behavior. Pig heart peroxisomal carbonyl reductase (PerCR) belongs to the short-chain dehydrogenase/reductase family, and its sequence comprises a C-terminal SRL tripeptide, which is a variant of the type 1 peroxisomal targeting signal (PTS1) Ser-Lys-Leu.

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The existence of cells that had been retrovirally labeled with green fluorescence protein (GFP) demonstrated the survival of implanted cells. Serum C-peptide levels were not significantly affected by food limitation (LFI 24, LFI 48, or LFI 120) as compared with controls, but when vitamin C was supplemented, the C-peptide levels were moderately enhanced. Using a qualitative research approach, interviews were conducted with 42 participants (35 men and seven women).

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Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3. However, it is possible that the greater enzymatic degradation observed in intestinal membranes might explain the differences in receptor sizes in the two organs. Putting all your eggs in one basket: egg safety and the case for a single food-safety agency. EFFECTS OF AIR TEMPERATURE AND HUMIDITY ON THE METABOLISM OF FOOD NUTRIENTS IN CATTLE AND BUFFALO BULLS.

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Ypt1 suppresses defects of vesicle trafficking and autophagy in Ypt6 related mutants. Experimental and control flush solutions were assayed for the presence of neutrophil chemotactic factors with the use of modified Boyden chambers. In patients with a first episode of anaphylaxis, posterior aetiological diagnosis is crucial to avoid the appearance of new episodes.

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According to the concentration gradient of each parameter, all samples were divided into a calibration set (3/4 samples) and a validation set (1/4 samples). ON THE INFLUENCE OF LOCAL OCCLUSIVE THERAPY WITH FLUORANDRENOLONE ON PSORIATIC SKIN REACTION. Fluorous effect in proteins: de novo design and characterization of a four-alpha-helix bundle protein containing hexafluoroleucine. Only a few cases were described in the literature and the association of both diseases is not obvious at first sight, although a common ciliary dysfunction of both respiratory epithelium and photoreceptors of the retina seems to be the common factor. In contrast to cystic neoplasms, pseudocysts are localized collections of inflammatory fluid that mimic cystic neoplasms.

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Effects of immunizing ewes against bone morphogenetic protein 15 on their responses to exogenous gonadotrophins to induce multiple ovulations. Immunohistochemical staining of FBJ virus-infected cells revealed intense, nuclear staining.

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A review of the literature reveals an incidence of abuse during pregnancy in approximately half of all battered women, and one in 11 to one in 50 women from the general population. Alveolar ridge augmentation using implants coated with recombinant human growth/differentiation factor-5: histologic observations.

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The two groups were matched for age, gender, IQ, ADHD subtype, symptom severity, comorbidity and medication status. In recent years, unprecedented advances in genome-wide sequencing, functional genomics technologies for RNA interference screens and methods for evaluating three-dimensional chromatin organization in vivo have resulted in important discoveries regarding human cancer. In patients given telaprevir alone, viral rebound can result from the selection of variants with greater fitness.

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Immunocytochemical reactions of serum from ulcerative colitis patients. pylori-positive were treated with clarithromycin 500 mg, omeprazole 20 mg, and amoxicillin 1000 mg, all given twice daily for 7 days.

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We have isolated cDNAs encoding the bHLH protein Hand2 in the amphibian Xenopus laevis and analysed Hand2 expression in early development from the onset of gastrulation to feeding tadpole stages. Plasma insulin activity was reduced 2 hours after injection of bromocriptine at a dose of 15 mg/kg Likewise, a significant reduction in plasma insulin activity was observed in response to daily I.P. In contrast, milk intake was significantly reduced by naltrexone (0.25-1.0 mg/kg) in Day-10 rats that obtained milk (a) by licking it off a saturated substrate or (b) through an indwelling cannula located in the anterior portion of the lower jaw. Studies on calcium metabolism in bone epi- and metaphysis after local roentgen irradiation.

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Furthermore, it damaged the sperm mitochondria significantly at sublethal concentration by the dissipation of transmembrane potential in the mitochondrial inner membrane, while the plasma membrane permeability barrier remained intact. In animals with a highly developed deep submucous plexus, terminal arterioles frequently passed through the muscle coat before breaking up into capillaries.

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IFNbeta-1a treatment and reestablishment of Th1 regulation in MS patients: dose effects. Image quality is further improved by a second weighting factor based on the spatial coherence of signals across the entire array. Two boys with congenital adrenal hyperplasia and known upper-tract genitourinary anomalies were also identified.