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Ledipasvir (Ribavirin)

Ledipasvir is used in combination with other antiviral medications (such as interferon, sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. Ledipasvir works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. It is not known if this treatment can prevent you from passing the virus to others. Do not share needles, and practice "safer sex" (including the use of latex condoms) to lower the risk of passing the virus to others.

Other names for this medication:
Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, Hepcvir, Incivek, Kipferon, Ledifos, Ledipasvir, Miravirsen, Multiferon, Olysio, Ombitasvir, Paritaprevir, Pegasys, Pegetron, Pegintron, Rebetron, Resof, Setrobuvir, Simeprevir, Sofab, Sofovir, Sovaldi, Sylatron, Technivie, Telaprevir, Veldona, Victrelis, Viroclear, Zepatier,

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To study the prevalence of metabolic syndrome (MS), insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) in overweight/obese children with clinical hepatomegaly and/or raised alanine aminotransferase (ALT). Ultrastructural study of hepatic mitochondrial abnormality in swine treated with clofibrate. Also encoded at this genomic locus is Rev-ErbA alpha (Rev), a non-T3-binding member of the T3/steroid hormone receptor family. Accident and Emergency (A and E) is the first port of call for most people who have experienced an injurious fall. Asthma control with extrafine-particle hydrofluoroalkane-beclometasone vs.

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We report here that members of the eba, rhoph1/clag, acbp, and pfRh multigene families exist in either an active or a silenced state. Several C----U transitions and small deletions were introduced into the conserved region centered on base C1400 in Escherichia coli 16S rRNA by in vitro mutagenesis. Plasmatocyte sensitivity to plasmatocyte spreading peptide (PSP) fluctuates with the larval molting cycle. The hybrid molecule replicates as a stable, unintegrated, multicopy plasmid in transformed mouse cells.

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Randomized clinical trials (RCTs) evaluating pharmacological agents in liver resections conducted under vascular occlusion were identified. Clinical usefulness of scintigraphy with 99m technetium phosphates in rhabdomyolysis Which interventions for non-specific neck pain are effective in reducing pain or disability?

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Study on the chemical constituents of roots and stems of Nardostachys chinensis When uniform and skewed habitats are coupled through migration of the organisms, we observe a primitive form of punctuated equilibrium. A non-functioning PCoA was found in 4 patients with idiopathic SSHL and in 4 cases in the control group.

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His compound muscle action potential and F-wave occurrence were reduced on a nerve conduction test. A total of 24 SpVc neurons that responded to orofacial mechanical stimulation were extracellularly recorded by means of multibarrel microelectrodes in urethane-anesthetized rats. Fluoxetine concentrations above 10 microM inhibited exocytosis almost completely but showed no other toxic effects on neurons. After a review of the literature, we summarized the advantages and disadvantages of various approaches related to surgical managements of the anterior lens capsule, posterior lens capsule, and anterior vitreous in pediatric cataract surgery. This death process involved reactivation of the caspase gene, Nedd-2, a developmentally down-regulated apoptotic gene.

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The inputs of the program are a table of yields of pairwise chromosome interchanges and a proposed chromosome geometric cluster. The tri-n-butylammonium salt of this LMWHP was O-acylated with butanoic, hexanoic, octanoic, decanoic, dodecanoic, and stearyl anhydrides separately to give respective O-acylated LMWHP derivatives. We determined that serotype AAV2/5 transduced A549 cells much more efficiently than serotypes AAV2/1, AAV2/2, AAV2/6, AAV2/7, AAV2/8, AAV2/9 and AAV2/10.

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Neurotrophins and their respective tropomyosin related kinase (Trk) receptors (TrkA, TrkB, and TrkC) and the p75 neurotrophin receptor (p75(NTR)) play a fundamental role in the development and maintenance of the nervous system making them important targets for treatment of neurodegenerative diseases. When the diagnosis is confirmed, MR imaging of the pituitary gland is performed. Our results suggest that alcohol intoxication increases microvascular permeability to plasma proteins. Utilization of these methods ultimately led to the rapid assembly of the northern bryostatin fragment containing both the ring A and B subunits.

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The area of the vessel wall (AreaVW) of assessed intracranial arteries and the ratio index (RI) of each patient were determined. jejuni NCTC 11168 does undergo certain changes in stationary phase, of a pattern not previously described.

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Complete removal of the tumour is the only treatment which is potentially curative provided that lesion is confined within the liver capsule. However, CD44v6, as opposed to CD44s, did not colocalise with the TCR/CD3 complex after CD3 cross-linking.

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Selective COX-2 inhibitors, such as meloxicam, celecoxib (SC-58635), and rofecoxib (MK-0966), are NSAIDs that have been modified chemically to preferentially inhibit COX-2 but not COX-1. Treatment consisted of intrapleural instillation of amphotericin B and nystatin followed by creation of an Eloesser flap.

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Synchronized electrical cardioversion may become necessary when signs of cardiac decompensation or hypotension were developed. Although chronic excessive exposure to sunlight increases the risk of nonmelanoma skin cancer, the avoidance of all direct sun exposure increases the risk of vitamin D deficiency, which can have serious consequences. Moreover, Instrument 2 demonstrated reasonably good rating scale function but exhibited construct underrepresentation and ceiling effects. Besides offering a way to consult with specialists in other parts of the country on medical problems or procedures, telemedicine programs allow primary care providers in isolated practice settings to communicate with colleagues and take classes to further their skills--something states hope will convince them to stay put.

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A variety of approaches has been shown to be effective in older adults and is easily accessible to the primary care, specialty, and inpatient practitioner. Pathomorphology of the central nervous system in acute liver damage

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The evolutionary origin of the lost alpha1,3GT enzyme activity is not yet known, although it has been suggested that the promoter activity of this gene in the ancestors of higher primates was inactivated. In case of colonic intussusception should not be performed any reduction because the frequent association with neoplastic disease. These data suggest that the combination of a limited adaptive immune response plus the anti-IAV drug oseltamivir is sufficient to curb high mortality and mediate resolution of IAVs in mice chronically consuming ethanol. In particular, high levels of serum triglycerides and free fatty acids were associated with altered levels and distribution of plasma cholesterol, with increased total and very low-density lipoprotein-low-density lipoprotein (VLDL-LDL) cholesterol and reduced high-density lipoprotein (HDL) cholesterol.

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The knowledge of factors that may influence blood donation in Cameroon is limited. A Japanese national project, the National BioResource Project (NBRP) for collection, maintainance, and provision of Drosophila resources, that is well known and admired by researchers in other countries as an important project, is also briefly described. Delayed long-lasting effects of such treatment on animal behavior were revealed. The genetic factors contributed substantially to the variation in the fertility and viability components.

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Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL. This advantage has led to the recognition that HRV infections are common causes for not only upper airway symptoms but also more severe lower respiratory illnesses. Topical treatment with steroids was useful to reduce inflammation and produced persistent remission in two patients. The effect of an impregnating solution on the pulp of teeth prepared for jacket crowns A multicenter, prospective, blinded study was performed to test the feasibility of using a handheld optical imaging probe for the intraoperative assessment of final surgical margins during breast-conserving surgery (BCS) and to determine the potential impact on patient outcomes.

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Small subunit (SSU) rRNA gene sequence data support the validity of both species. Enhance immune response to DNA vaccine based on a novel multicomponent supramolecular assembly. Eight laboratories conducted a test for the estimation of the bioavailability of iron from 4 sources, using depleted male albino rats. Weanling outbred mice were more than 500 times less susceptible to orally administered mouse adenovirus (MAdV) strain K 87 than to MAdV-FL.

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Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome. By using high-resolution fixed-tissue microscopy and two-photon imaging in living mice we observed that a large fraction of microemboli infused through the internal carotid artery failed to be lysed or washed out within 48 h. The definition of these grouping characteristics and their design needs seem to be the most important challenge for the sport shoe researchers and manufacturers for the near future. Since the discovery of the prion protein (PrP) and its role in transmissible spongiform encephalopathies, the need to obtain large quantities of the recombinant protein for research purposes has been essential.

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32 patients with liver cirrhosis were studied by endoscopy and duplex sonography. Surgical management of meningiomas involving the optic nerve sheath. Both kinases suppress SFKs by selectively phosphorylating their consensus C-terminal regulatory tyrosine. Different synaptic location of mianserin and imipramine binding sites.

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Demographic data, assessment of dysmenorrhea, and follow-up 1, 3 and 6 months after IUD replacement were recorded in questionnaires designed for this purpose. Exposures that may affect sperm DNA integrity: two decades of follow-up in a pregnancy cohort. Synthesis and structural variations of substituted phenylamide complexes of the heavy alkaline earth metals calcium, strontium and barium.

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Proteome analysis of cerebrospinal fluid in healthy beagles and canine encephalitis. Application of microdroplet PCR for large-scale targeted bisulfite sequencing. The anaesthetic techniques for caesarean section and the level of training of the attending anaesthetist were noted. In systems of coupled oscillators, the effects of complex signaling can be captured by time delays and phase shifts.

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The performance of glomerular filtration rate (GFR) equations incorporating both cystatin C (CysC) and serum creatinine (Creat) in living kidney donors has not been studied before. Over the past decade, much effort has been placed towards developing plasmepsin inhibitors as antimalarial agents, particularly targeting the digestive vacuole. We conclude that significant changes in predicted outcomes will occur when the experimental results are applied to the numerical model, where the direction and degree of change varies with the electric field considered. Effects of basic fibroblast growth factor composite sponge treated collagen on vascularization of orbital implants: a histopathologic analysis In vitro, IFN alpha production by Sertoli cells, peritubular cells, and early spermatids was inducible by the Sendai virus, whereas pachytene spermatocyte IFN alpha production was not triggered by this virus.

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AlPase is present in the abundant network of stratified and concentric membranes from which a large number of pinocytic vesicles arise. Clinical experience however shows that the achieved remission of malignant tumour illness after non-adjuvant chemotherapy is only temporary and short-lived. Disruption of DYH7, the gene which encodes Dyh7p, was confirmed by PCR examination of both genomic and cDNA templates.

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Arm-reach capability of USAF pilots as affected by personal protective equipment. The masseter muscle of rats in the saline and the BTX-A group were administered with saline and BTX-A solutions respectively. Expression of endogenous lectins in human small-cell carcinoma and undifferentiated carcinoma of the lung.

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Characteristics of the corresponding gene, THR1, and the purified enzyme, and evolutionary relationships with other enzymes of threonine metabolism. The cumulative number of HIV cases reported up to 1996 was nearly equal to the number estimated by the above-mentioned method. Age-related impaired function also associates with phenotypic alterations of microvascular cells, such as endothelial cells, smooth muscle cells and pericytes. The purpose of this study was to determine the genetic variability of vectors from Campeche coastal and rain forest areas and establish a phylogenetic relationship with other T.

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Log-transformed urine and hair levels were modeled in multivariable linear regression separately against respective exposure surrogates, and the effect modification of 13 MT SNPs on exposure was investigated. They may originate from various primary sites, mainly kidney, lung, breast, esophagus and uterus.

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Structured triacylglycerols (TAGs) were isolated from nine cultivated strains of microalgae belonging to different taxonomic groups, i.e. The level of the spine and the incidence of inadvertent intravascular injections were recorded.

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The variables of lack of leisure activities, higher education and/or lack of tobacco-related disease correlated with failure to quit smoking among smokers who sought treatment at an outpatient clinic in a tertiary general hospital. Specific membrane receptors for diferric-transferrin in cultured rat skeletal myocytes and chick-embryo cardiac myocytes. Data were obtained from the Faroe Islands, Iceland, and Denmark on systemic antibacterial use and expressed in defined daily dosages (DDD). Available heuristics dedicated to each of these problems are computationally costly for even small instances. These preliminary findings suggest that embedding the PIs of students with autism spectrum disorder within readings may result in more accurate responses to reading comprehension questions and more detailed oral retelling.

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A Bayesian method for estimating the amino acid distributions in the states of a hidden Markov model (HMM) for a protein family or the columns of a multiple alignment of that family is introduced. During that time there was a continuous change from an immediate flow-related distribution toward a more specific receptor distribution.

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Participants were administered the Health Behaviour in School-Age Children Survey in 2006 and then again in 2007, and included 1,738 youths from 17 Ontario high schools. In our cases the severity of the lesions was not related to age, sex, type of operation or anaesthetic or the duration of the anaesthetic. Higher education results in a higher intention to eat fish but has no effect on the consumption frequency itself.

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The amino acid sequence of the transit peptide indicates that the polypeptide is routed towards the stroma side of the thylakoid membrane. Unfortunately, they were applied to retrospective investigations rather than used as an aid in the health care system. By proton nuclear magnetic resonance spectroscopy, the enzyme was found to act by inverting the beta-anomeric configuration. plantarum biotypes, for their proper use in winemaking processes which are distinctive for each wine. Towards the determination of isoprene in human breath using substrate-integrated hollow waveguide mid-infrared sensors.

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The potential benefits of surgery should be assessed carefully in patients with any of these risk factors. The data and results obtained from this study confirmed that the functional behavior of partial dental prostheses with supporting abutments and soft tissues are consistent with the conventional theories of design and clinical experience. Enhanced diltiazem bioavailability after oral administration of diltiazem with quercetin to rabbits. When performing an orthopaedic device implantation, it should be routine practice for the surgeon to ask the patient if he or she has a metal allergy, and more specifically a nickel allergy. Here, we present a 29-year-old male with no cardiovascular history and a low atherosclerotic risk profile who developed AF which converted into sinus rhythm immediately after a digital rectal exam.

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These findings suggest that some aspects of the eye-mind link are flexible and can be configured in a manner that supports efficient task performance. In a patient with Holmes-Adie syndrome, and in another with tabes dorsalis, a transverse cord lesion resulted in a severe, but flaccid paraplegia with absent tendon reflexes. The approaching era of interferon-free directly acting antiviral therapy has the potential to provide one of the great advances in clinical medicine. This responsibility extends to all medical educational institutions. Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT.

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Data collection was prospective, and follow-up was completed at 90 days after stroke. Apgar scores and cord blood gases (BG) and pH were compared between a group of babies with nuchal cords and a group without nuchal cords and uncomplicated deliveries. We looked for CHFR gene (605,209) alterations and its promoter hypermethylation in 48 ovarian carcinomas either sensitive or resistant to taxane treatment. Because of the removal of silanophilic interactions, minimisation of hydrophobic interactions, and the highly flexible nature of the tentacle-like ion exchangers, ionic interactions can therefore dominate the separation. The transformation of young thymic lymphocytes into peritoneal exudate cells demonstrated by transfusion of labelled cells.

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Pharmacological and patch-clamp studies identified L-type calcium channels as crucial effectors of antiapoA-1 IgG chronotropic action, involving two converging pathways that increase the channel activity. We will review the mechanisms of how the thymus contributes to the development and selection of T cells, with emphasis on the establishment of self-tolerance in the thymic medulla.

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Benzodiazepine agonists protect a histidine residue from modification by diethyl pyrocarbonate whereas propyl beta-carboline does not. AGP measurements identified limited-disease patients more frequently than LDH or CEA, and a combination of markers (AGP and LDH) improves the accuracy of correctly classifying patients with active disease.

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Patient age ranged from 3 to 58 years (mean 21) and all except 1 had sustained a pelvic fracture urethral injury as the initial causative trauma. Reflex stimulation of heart induced by partial occlusion of pulmonary artery. It highlights the importance of recommending HAV vaccination to foreign nationals and their families who are travelling to countries endemic for hepatitis A. The CBCR Tlr0924 contains both phycocyanobilin and phycoviolobilin chromophores, and these two species photoisomerize in parallel via spectrally and kinetically equivalent intermediates before the second step of the photoreaction where the reaction pathways diverge, the loss of a thioether linkage to a conserved cysteine residue occurs, and the phycocyanobilin reaction terminates in a red-absorbing state, whereas the phycoviolobilin reaction proceeds more rapidly to a final green-absorbing state. Despite good treatment, there are residual risks in acute myocardial infarction (AMI) patients, and low level of high-density lipoprotein-cholesterol (HDL) has drawn attention as a possible cause.

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By contrast, extravillous trophoblast showed an intense reaction for HLA-A, -B and -C. We also used a combined liver comet assay and equate omeprazole magnesium inactive ingredients in nexium bone marrow micronucleus assay using C3H-derived constitutive androstane receptor knockout (CARKO) and wild-type mice. Catheter-associated bloodstream infection (CA-BSI) is the most common nosocomial infection in neonatal intensive care units. The severity of anaphylaxis was associated with mast cell degranulation, increased plasma heparin levels, the intensity of contact system activation, and bradykinin formation. It was further observed that parameters representing various ability of movements might yield an alternative regression formula and that the accuracy in age estimation was improved with application of a second-order regression formula.

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A peculiar pattern was revealed by indocyanine green videoangiography. Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. In obese patients undergoing bariatric surgery, abnormal preoperative spirometry predicts postoperative respiratory lanzap drug abuse complications only in patients with OSAS. A 1-year-old girl was referred to us with subcutaneous induration of the right upper eyelid. BCR-ABL-negative myeloproliferative neoplasms include primary myelofibrosis, polycythemia vera, and essential thrombocythemia.

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It is assumed that catecholamine, glucocorticoid and glucagon do not play an important role in the inhibitory mechanism of insulin secretion during hypothermic open-heart surgery, and a transient hypofunction of the pancreas as well as the liver and the adrenal gland is probably involved. Enhancement of humoral immune responses to HBsAg by heat shock protein gp96 and its N-terminal fragment in mice. It is more likely that the auditory and vestibular effects of the loss of prosaposin are mediated through the actions of saposin A and/or B. The advantage of using spore outgrowth and germination is that a highly synchronized population of bacterial cells can be obtained. We discuss how single nortriptyline cause weight gain molecule biophysics is poised to transform our understanding of biological systems, in particular DNA repair.

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To investigate the effects of these drugs on HERV transcriptional activity, HERV expression lamotrigine depression dosierung omega-3 profiles of a broad range of human brain cell lines treated with valproic acid (VPA), haloperidol, risperidone, and clozapine were analyzed using a retrovirus-specific microarray and qRT-PCR. 1,25-Dihydroxyvitamin D3 metabolism in a human osteosarcoma cell line and human bone cells. Genotoxicity studies on the organophosphorus insecticide chloracetophone. Analysis of previously secret tobacco industry documents and multimedia materials. Demonstration of tolerance and physical dependence in the dog following a short-term infusion of morphine.

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Lung dose calculations for inhaled radon decay pret sumetrolim capsule products presented in part I have revealed that mean basal cell doses are significantly dependent on various personal and environmental factors. Air kermas in radiographic mode were measured with 0.6 cc ion chamber and Unidos electrometer for Synergy-integrated XVI kV cone beam CT unit. Purification and characterization of a type II casein kinase from Drosophila melanogaster. Mutations in X-linked ichthyosis disrupt the active site structure of estrone/DHEA sulfatase.

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The decrease in plasma cholesterol could also be due to inhibition of cholesterol synthesis by propionic acid or to modifications in the bile acid metabolism. A comparison of the image processed digitized Fourier transforms for the scales was made on a personal tadalista super active 20mg roxy computer. The beneficial effect of PTCA on autonomic balance was greater in patients with well-preserved carotid artery distensibility than in those with impaired carotid artery distensibility. A survey of factors associated with the utilization of community health centers for managing hypertensive patients in Chengdu, China.

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Its generation is best explained by assuming that the entire 23 kb Tn2671 transposon has undergone intramolecular replicative transposition. The participating nursing students with clinical placements in nursing homes assessed doxepin and sleep apnea their clinical learning environment significantly more negatively than those with hospital placements on nearby all sub-dimensions.

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Alterations in hepatic lipid metabolism mebendazole 100 mg dosierung ramipril induced by acclimation to low environmental temperatures. Effect of cooking method (baking compared with frying) on acrylamide level of potato chips. Both were biochemically typical Escherichia coli O5 :H(-), apart from producing urease. A contribution to the knowledge of congenital ichthyosiform conditions of the skin