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Bruce Shields was first to use this term to describe a localised, physiological pigmentation of the optic nerve neuroretinal rim tissue that is distinct from peripapillary pigmentation. Neural activity-dependent regulation of gene expression in developing and mature neurons.

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A defect in the type II receptor might cause unresponsiveness to TGF-beta in F5-5.fl cells. Development of anti-obesity agents: drugs that target neuropeptide and neurotransmitter systems. Seven of these had pathology within the appendix and 1 was histologically normal. Stroke is a devastating event that carries a potential for long-term disability.

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Effects of age and sex on immunological and virological responses to initial highly active antiretroviral therapy. We investigated a potential dual role for NOTCH in joint maintenance and osteoarthritis by generating two mouse models overexpressing the NOTCH1 intracellular domain (NICD) within postnatal joint cartilage. Similarities and differences in the therapeutic use of mud and peat

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Physiological conditions that alter the properties of the barrier include severe exercise in elite human athletes. Locked plates reduce displacement of vertically unstable pelvic fractures in a Mechanical Testing Model. The fuller the buffer the slower the cellular uptake of phosphate, to the point that in phosphate-replete tropical waters, cells can saturate their buffer and their phosphate uptake becomes marginal. Injection of the alpha 2-noradrenergic antagonist, yohimbine, caused a decrease in the concentration of estrogen receptors in mediobasal hypothalamus.

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Comprehension of concrete and abstract words in patients with selective anterior temporal lobe resection and in patients with selective amygdalo-hippocampectomy. Condition of myocardial blood vessels after irradiation of the heart region Amyloid-beta disrupts calcium and redox homeostasis in brain endothelial cells. The advent of robust, rugged, and current Good Manufacturing Practices (cGMP) compliant hand-held Raman spectrometers provides a wealth of opportunities for the analytical pharmaceutical chemist to bring the laboratory to the sample.

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We analyzed the self-similarity of normal heart rhythm, congestive heart failure and sudden cardiac death signal in the present paper using detrended fluctuation analysis (DFA), in order to achieve these two pathological ECG signal detection. The estimated conduction velocity (CV) of the group II afferent fibres was lower in CMT2 and Diabetics than in normal subjects and CMT1A. Should all specimens taken during surgical treatment of patients with benign prostatic hyperplasia be assessed by a pathologist? The objectives of this project were to ferment cucumbers in brine containing CaCl(2) as the only salt, to determine the course of fermentation metabolism in the absence of NaCl, and to compare firmness retention of cucumbers fermented in CaCl(2) brine during subsequent storage compared to cucumbers fermented in brines containing both NaCl and CaCl(2) at concentrations typically used in commercial fermentations.

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The median final dose for the responding group was 120 U/kg three times per week to maintain a hematocrit greater than 0.38. Stereochemical effects of 11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor.

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In all, tightness-looseness provides a parsimonious explanation of the wide variation we see across the 50 states of the United States of America. Rights maintenance and self-discipline of practicing dentist: part VI. Prolactin was secreted in a daily rhythm, with the highest concentrations occurring early in the photophase. Resistance of red clover (Trifolium pratense) to the root parasitic plant Orobanche minor is activated by salicylate but not by jasmonate. These reflect the presence of antigen-specific IgE, but this test is not specific for ABPA, as other atopic subjects may also be sensitized to A.

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Freshly isolated ductal fragments were placed on a rocker in M3:5 medium free of collagen for 14 days to remove fibroblasts and endocrine cells before allowing them to attach. In addition to these, we have systematically analyzed the changes in components of the square of the radius of gyration parallel and orthogonal to the surface, as well as the intermolecular and intramolecular vdW energy of the PE chain when it transforms to monolayerlike, lamellalike, and polylayerlike configurations. Female Lister hooded rats were exposed to nicotine solutions both before and during pregnancy.

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Attention to CVD screening may be an important target in school, community, and healthcare arenas for minority populations regardless of weight status. Cerebellar reactions during rotation of animals in a centrifuge with different schedules of operation Hidden factors that may increase the likelihood of both early life antibiotic prescription and later asthma are an increased susceptibility to viral infections consequent upon impaired antiviral immunity and genetic variants on 17q21. Pre- and post-course multiple choice questionnaires were completed by 1177 course attendees.

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4/38 patients with multiple samples presented molecular discordant data. Variation of ultrasound image lateral spectrum with assumed speed of sound and true scatterer density. At higher doses than normally used therapeutically, BAC caused significant nasal irritation. Structural alterations to the benzylic position of the first drug-like selective angiotensin II AT(2) receptor agonist (1) have been performed, with the emphasis to reduce the CYP 450 inhibitory property of the initial structure.

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The safety and health improvement: enhancing law enforcement departments study: feasibility and findings. This has the potential to decrease the burden of disease and reduce disparity in disease outcome. Preoperative measurement of sTNFRI could potentially serve as a reliable indicator for prophylactic treatment with an anti-TNF therapy.

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The inhibitory effect of Cav-1 expression on the Akt-endothelial nitric oxide synthase pathway was specific because VEGF-stimulated phosphorylation of mitogen-activated protein kinase (ERK1/2) was elevated in the Cav-1 transgenics, compared with littermates. Our study highlights the value of systems biotechnology to understand glycoprotein synthesis and product glycoprofiles. These capsomeres appeared to be broad headed and short stemmed, similar to the type of pin used to mark locations on a map (pushpin). The F cells appeared to be derived mainly from host tissue, as they contained a normal diploid complement with sex chromosomes corresponding to the sex of the host.

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Cyclin-dependent (CDK) and Dbf4-dependent (DDK) kinases trigger DNA replication in all eukaryotes, but how these kinases cooperate to regulate DNA synthesis is largely unknown. The spontaneous cessation of illness came in 8 patients after approximately 5.75 years. Essential considerations in the provision of near-patient testing facilities.

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Impaired emotional responsiveness has been revealed as a hallmark of psychopathy. Elbow extension as a diagnostic test in a primary care setting can predict severe elbow injuries and can be safely used in practices with no radiology facilities.

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Thus, 1 functions as a molecular peptide beacon, and as it is easily taken up by cells, 1 can also be used for imaging of nucleic acids within cells. Inhibition of fermentation of macerated yeast juice by rat liver mitochondria. Structural and electronic snapshots during the transition from a Cu(II) to Cu(I) metal center of a lytic polysaccharide monooxygenase by X-ray photoreduction. Economic evaluation of the antibiotic treatment of exacerbations of chronic bronchitis and COPD in primary care. Mean patient age was 27 years (range 16-29 years) and time from the accident to ligamentoplasty was 29 months (range 3-156 months).

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Expression of both firefly luciferase and alkaline phosphatase reporter genes increased up to 8-fold and DNA copy numbers in muscle increased up to 6-fold. Initial validation of a novel rat model of vasculogenic erectile dysfunction with generalized atherosclerosis. Total 28 microRNAs were up-regulated and 30 microRNAs were down-regulated in cluster 5. We asked the clinician group to indicate their level of agreement with the Delphi panel for each measure using a five-point scale (much too high, slightly too high, reasonable, slightly too low and much too low).

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Five-week-old mice were primed on day 0 with ovalbumin intraperitoneally. To provide a comprehensive overview of stress in patients diagnosed with lung cancer within the context of the four perspectives (normal physiologic, pathophysiologic, behavioral, and experiential) of the Human Response to Illness Model. These findings establish that CD95 is a critical regulator of effector T cell homeostasis in chronic immune activation. The foreclosure crisis has likely contributed to increased suicides, independent of other economic factors associated with the recession.

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Dipyridamole reduces urinary albumin excretion in diabetic patients with normo- or microalbuminuria. The various stages of TK program implementation range from those during drug discovery and selection to support of chronic toxicity studies. The incidence of oligophrenia, psychopathia and alcoholism in 79 families of schizophrenics

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Restoration of chromosome aberrations of irradiated tumor cells by DNA and its precursors. Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules.

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This study sought to understand if shared decision making and/or receipt of mental health care was associated with patient satisfaction for patients with depression and to determine whether gender modified this relationship. The role of carotenoids in the formation of lipofuscin and the adaptation of animal cells to oxygen insufficiency Repositioning accurately the nasal structures is enough if we are able to control the healing process and prevent endonasal wound contraction. Lee plate equations for high-frequency vibrations of piezoelectric plates have been established and improved over the last decades with the sole objective of obtaining the accurate prediction of frequency and mode shapes to aid crystal resonator design. Venous blood was collected before, and 30 and 60 min after consumption of the drinks.

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Disruption of ECF in substance abusers could interfere with attempts to stop drug use and undermine treatment. General thermodynamic considerations are used to derive in Clapeyron-like equation for the rate of variation in membrane transition temperature with divalent cation concentration. We tested the hypotheses that there are differences in the peri-operative course of brake response time in patients undergoing right-sided (1) or left-sided (2) UKA.

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Normal and mutant MYOC cDNA constructs were used to transfect the TM cells. The enantioselective construction of a fully functionalized core structure of (-)-CP-263,114 (1), containing most of the required functionality for total synthesis, was conducted through sequential radical fragmentation-reductive olefination. Preservation of function may serve as a meaningful outcome for intervention efforts. Theoretical and practical considerations on the use of reassurance in the nursing management of anxious patients. We suggest that the mouth primordium was located at the anterior neural boundary, in early chordate evolution.

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It also occurs sometimes in patients on hemodialysis, where it is a potentially lethal complication. Thus, the developed methodology can also be utilized to the quality evaluation of Xingnaojing injection, in spite of the difference found in the content of curzerenone between the external standard method and the newly established method. MSMs are increasingly being used to provide information to guide health policy decisions.

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There have been considerable advances in uncovering the complex genetic mechanisms that underlie nervous system disease pathogenesis, particularly with the advent of exome and whole genome sequencing techniques. Seventy one of 1078 designed molecular genetic markers were used to screen M. The change of serum vascular endothelial growth factor and matrix metalloproteinases-9 in proliferative hemangioma treated with propranolol The highest regeneration percentage was slightly higher (22 percent) than that measured with apical buds, and was also achieved after 135 min PVS2 exposure.

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Some previous studies conducted in African countries suggested that appropriate use of a partogram with standardised monitoring was associated with good labour outcomes. We conclude that seeking unidimensional answers to the question of why isolated human groups generally experience few allergic conditions is potentially flawed because allergies are produced by a multifaceted immunoglobulin E (IgE) system that responds in complex ways to the environmental and behavioral exposures we examined. Recent advances in computer-aided drug design as applied to anti-influenza drug discovery. Recent advances in fundus photography allow for improved accuracy and consistency in interpretation of funduscopic lesions, and improve the feasibility of screening for these abnormalities in at-risk patient populations. Tissue penetration characteristics of ceftizoxime and cefazolin in human bile and gallbladder wall.

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In order to accurately model longitudinal change, the acquisition parameters should thus be considered in statistical models. High concentrations of leptin (LEP) contributing to an increased blood pressure in obese patients via increase in the activity of the sympathetic nervous system.

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Fourteen adults were given placebo or short-acting MPH (0.5 mg/kg) in a randomized, double-blind, placebo-controlled crossover fashion. The presence of BKV DNA in urine samples was evident in 3/15 patients without HC and in 5/5 patients with HC.

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Results from small-scale randomized studies on the effectiveness of different preparations of nitric oxide donors in cervical priming before first trimester termination of pregnancies are not consistent. Occupational health services (OHS) evolved in response to the needs of hazardous industries and on the premise that work was harmful. Triglycerides are major determinants of cholesterol esterification/transfer and HDL remodeling in human plasma.

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Antibiotic Prophylaxis to Prevent Surgical Site Infections in Children: A Prospective Cohort Study. Chromatographic profiles of RNA: methodology and protein association. It would be rash to conclude, however, that G-CSF-based stem cell therapies for repairing the injured or failing heart are not worth pursuing. EFFECT OF AN ANTIBIOTIC ON LIPID FRACTIONS IN PLASMS AND EGG YOLK OF LAYING HENS. Modification, biological evaluation and 3D QSAR studies of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-yl)phenol derivatives as inhibitors of B-Raf kinase.

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Two babies are described with oesophageal atresia, a tracheo-oesophageal fistula and severe subglottic tracheal stenosis. The conventional finite element method (FEM) was used to calculate stress distribution. After obtaining baseline postoperative radiographs, additional radiographs during the first year after surgery for IS may not be required in the absence of clinical symptoms.

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Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling. This abrogation of the FA/BRCA pathway by phenylbutyrate was not due to loss of FANCD2 monoubiquitylation but rather correlated to a phenylbutyrate-mediated reduction in the expression of the BRCA1 protein. bretschnrideri, Pyrus pyrifolia, Pyrus ussuriensis, and Pyrus sinkiangensis, were compared with those in 5 cultivars of Occidental pear (Pyrus communis).

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Factor Structure and Internal Validity of the Functional Movement Screen in Adults. An 84-year-old woman of Caucasian background presented with 12 months of worsening abdominal pain, nausea, vomiting, diarrhea and weight loss on a background of known gastric ulcer disease. Cell death via apoptosis is an important event involved in a number of immunological processes. In addition, the integrity of the tracheal anastomosis should be ensured by an omental wrap.

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Carbapenemase activity detection by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Hemodynamic variables, intraoperative opioid requirements, postoperative pain scores and analgesic requirements and complications were recorded.

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We have used cloned EcoRI fragments of the human CMV (HCMV) genome, strain AD169, to prepare restriction endonuclease maps of the DNA. These interventions expose the baby to several blood donors, hence the risk of infection and exchange transfusions. Numerical FEM calculations were critically compared with the results of various approximated formulas, unit cell models, and experimental data for different porous piezoceramics.

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By inhibiting the enzyme activity with chelators, the arthritic process could be slowed. Monoclonal antibodies 2G4, M2, and M7, which neutralize a number of serologically distinct rotaviruses, required amino acids 247-474 of VP4 for binding.

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A 2-year-old-boy was admitted for a 2 day history of decreased activity with ataxic gait. Antibodies which block PD-1 / PD-L1 interactions have demonstrated remarkable activity in a number of solid tumor subtypes. Positive reinforcement and behavioral deficits of autistic children. Subsynovial vascular arcades run along the insertion of the discus on the joint capsule, both on sternal and on clavicular sides. Inadvertent administration of vitamin K could have been related to an acute reduction in hemoglobin concentration.

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The amount of film draining upward is altered by varying the distance between the frame and magnet. A 61-year-old woman presented with solitary lymphadenopathy suspicious for lymphoma. Litter weights, litter sizes, length of fetuses, number of implantation sites, and incidences of resorption in utero were the same in smoke-exposed and control animals. Interstitial pneumonitis induced by gemcitabine is rare, but could lead to severe complications, which could develop after long-term administration and should be treated by corticosteroid as soon as possible. Experimental studies have demonstrated a locally expressed RAS in the carotid body, which is functional significant in the effect of angiotensin peptides on the regulation of the activity of peripheral chemoreceptors and the chemoreflex.

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Incubation with an analog of the second messenger cyclic adenosine monophosphate increased both NAT activity and SR numbers. These agents caused particle diminution (diminution of cluster frequency but not of average cluster size), with or without cyclic nucleotide. Molecular basis of exopeptidase activity in the C-terminal domain of human angiotensin I-converting enzyme: insights into the origins of its exopeptidase activity.