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Prograf (Tacrolimus)

Prograf is the generic name for the macrolide immunosuppressant previously known by its experimental name FK506. Prograf was first discovered while screening for antibacterial activity of a multitude of compounds. This macrolide is produced by Streptomyces tsukabaensis, a bacterium found in the soil near Tsukuba, Japan. The mechanism of action of Prograf is closely related to that of cyclosporine. However, while Prograf binds tightly to the cellular protein named FKBP (FK506-binding protein) 12, cyclosporine binds cyclophilin. The target of either drug/intracellular receptor complex is a calcium-activated phosphatase called calcineurin, which is required for many functions in a variety of tissues: learning and memory, renal function, and immune responses. The selective sensitivity of immune function to these drugs has two reasons: 1. the low level of expression of calcineurin in lymphocytes relative to cells in other tissues; 2. an absolute requirement for calcineurin in immune activation. During antigen specific T-cell activation intracellular calcium is released and calcineurin is activated to dephosphorylate its target proteins including the transcription factor NFAT (nuclear factor of activated T cells). Upon dephosphorylation, NFAT translocates to the nucleus, where it binds its nuclear counterpart to form an active transcription factor inducing the production of several cytokines mandatory for initiating an immune response. Hence, calcineurin inhibitors interfere with antigen specific T-cell activation. Furthermore, Prograf affects the function of mast cells, basophile leucocytes and Langerhans cells. These characteristics explain the great interest to apply Prograf topically on inflamed skin, particularly since it was the first new topical immune suppressant since the introduction of steroids. The first successful use of topical Prograf in patients with atopic dermatitis was reported by Nakagawa et al. in 1994 and already 6 years later the U.S. Food and Drug Administration (FDA) approved Prograf ointment as a promising treatment for atopic dermatitis. Additionally, Prograf was investigated for a wide variety of inflammatory skin diseases beyond atopic dermatitis; particularly for conditions recalcitrant to other forms of therapy.

Other names for this medication:
Tacrolimus, Advagraf, Envarsus, Prograf,

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Hydralazine (10(-5) mol/l), a strong antioxidant, ameliorated tolerance to IS-5-MN, but did not affect the absence of tolerance to either ketoxime. Maximal spectral amplitudes of the flow fluctuations were below 5 Hz (bulk flow velocity 4-15 cms(-1)). The findings are discussed in terms of possible effects on central information processing mechanisms. Series: Clinical study from Japan and its reflections: j-Cypher Registry BMSCs are a class of multipotent, self-renewing cells that give rise to differentiated progeny when implanted into appropriate tissues.

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In female rats, maternal separation and handling did not significantly alter interpositus neuron number, volume, or GR protein expression, and GR expression did not correlate with eyeblink conditioning. We compared sex-specific mortality rates and examined male-to-female mortality rate ratios (MRR).

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Forced expression of RhoGDI2 attenuated cisplatin-induced apoptosis, whereas RhoGDI2 depletion showed opposite effects in vitro. Seasonal variations of archaeal and bacterial ammonia oxidizers (AOA and AOB) and anammox bacteria, as well as the environmental factors affecting these groups, are not well studied. This is of relevance considering a potential application of leptin in immunotherapeutic approaches and its possible use as adjuvant in vaccination protocols. The nuclei of the cochlear nerve of the red kangaroo, Megaleia rufus.

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TG was diagnosed in 86 renal allograft biopsy specimens (BS) obtained from 50 renal transplant patients followed up at our institute between January 2006 and October 2012. The effect of the cardioprotective Mediterranean diet on the development of cardiac abnormalities and prognosis of cardiac patients has rarely been investigated.

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The transition between the two metastable electronic states can be induced by different external stimuli such as temperature, pressure, light, or pH suggesting the use of these systems for molecular switches. Clinical and neuropatholgoical studies of 10 cases of Marchiafava-Bignami disease To distinguish between these possibilities, Experiment 2 measured temporal resolution, using backward masking and amplitude modulation detection, in the prospectively studied group of children when they were 8 years old. Observations on the epidemic of influenza in 1959 with special reference to complicated cases

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The identification of cholesterol crystals may provide significant help in diagnosing the real frequency and severity of this complication. Nevertheless, available findings seem to indicate that the renoprotective effect of these agents is at least partially independent of a better BP control. Using inducible beta(1) integrin-knockout bone marrow-chimeric mice we demonstrate that IEL expression of alpha(1) and alpha(2) but not alpha(4) is dependent on expression of the beta(1) chain. Finally, the association between PSE and in-group favoritism remained positive even when the in-group was objectively less favorable than the out-group (Study 4).

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Artemisinin (1 to 300 microM) inhibited I(K.ACh) induced by extracellular application of both carbachol (1 microM) and adenosine (10 microM) and that induced by intracellular loading of GTPgammaS (100 microM) in a concentration-dependent manner. Peritonitis has a significant impact upon morbidity and mortality of peritoneal dialysis (PD) patients.

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Most of the lactic acid bacteria were inhibitory, but other groups of bacteria contained more stimulatory cultures than inhibitory ones. 86 normal chinese adults divided into two age groups tested by the system under 6 standing postures, and a series of normal values of 7 balance parameters and 3 curve diagrams were then obtained.

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In a 50 year old man who complained of cough and sputum, a small endobronchial tumour was found in the left main bronchus and was biopsied via bronchoscopy. Effect of diabetic case management intervention on health service utilization in Korea. bombi at the doses we tested, and frass samples did not provide accurate estimates of the intensity of N. To compare the risk of HBV reactivation and HBeAg seroreversion between patients with spontaneous and NA-induced HBeAg seroconversion.

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365 community pharmacy staff members had interactions with shopper-patients. To assess the diagnostic utility of MAC deposition in distinguishing dermatomyositis from other neuromuscular disorders. The results of this study suggest that GSTP1 polymorphism might modulate the risk of endometriosis with significantly decreased risk for GSTP1 val/val and marginally increased risk for GSTP1 ile/ile.

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Is the prophylactic use of antiemetics in surgical patients justified? Randomized trial of 8 Gy in 1 versus 20 Gy in 5 fractions of radiotherapy for neuropathic pain due to bone metastases (Trans-Tasman Radiation Oncology Group, TROG 96.05). vaccae increased protection defined by significantly smaller ulcer size in immunized mice compared with the PBS-injected control group. In this study the performances of two systems, quantitative gated SPECT (QGS) and 4D-MSPECT, in the processing of clinical patient data and phantom data were compared. Two diabetes-specific measures were administered: ADS and DSC-R.

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Total opacification of a lung field visualised on conventional portable films may be due to infiltration and/or fluid and/or collapse by using the clinical information in conjunction with densitometric measurements. Electrochemistry of sinapine and its detection in medicinal plants.

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The cross-validation showed that the prediction map could estimate the distribution of snails in the marshland of Jiangning correctly. The assessment of subsets of intrahepatic lymphocytes and peripheral blood lymphocytes was done using flow cytometry and immunohistochemical study. Quantification of BRAF V600E alleles predicts papillary thyroid cancer progression.

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Methodology in the evaluation of the changes in autonomic regulation during acupuncture Ex vivo assessment of vascular response to coronary stents by optical frequency domain imaging. To compare the efficacy, safety, and acceptability of treatment with intravenous antibiotics for cellulitis at home and in hospital. One patient became jaundiced, one had a rash, and one showed granulocytopenia. A study of normal liver and livers with chronic hepatitis and cirrhosis.

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Usefulness of the 14-3-3 test for the diagnosis of sCJD evaluated by a Spanish reference center As development progressed, ncs-1a mRNA was present throughout the embryo with expression detected in ventral hematopoietic mesoderm, pronephric tubules, CNS nuclei, and otic vesicle. Dipole tensor-based atomic-resolution structure determination of a nanocrystalline protein by solid-state NMR. Protein microarray biosensors based on ketoconazole foam buy imaging ellipsometry techniques and their applications.