Sildenafilo is one of the best-known treatments for erectile dysfunction (ED). ED is caused by insufficient blood flow to the penis, resulting in the inability to maintain an erection. Sildenafilo can dramatically enhance the quality of an erection by increasing blood flow to the penis. Its effect lasts for 4-6 hours. Sildenafilo is widely known to treat PAH (pulmonary arterial hypertension). Sildenafilo is an anti-impotence drug which enables men to achieve and sustain an erection. The active ingredient of Sildenafilo is PDE-5 inhibitor. In response to sexual arousal, Sildenafilo stimulates the release of nitric oxide (NO) in the corpus cavernosum. Nitric oxide activates the lyase enzyme which is followed by increasing levels of cyclic guanosine monophosphate (cGMP). This cyclic nucleotide relaxes smooth muscles in blood vessels of the corpus cavernosum, increasing blood flow and thus inducing an erection. Along with the treatment of erectile disorders, Sildenafilo effectively prolongs sexual performance, preventing premature ejaculation (PE). Sildenafilo is also used in the treatment of PAH (pulmonary arterial hypertension).
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