Topamac was first approved in the United States in 1996 for treatment of epilepsy. Topamac has gained additional approvals for treatment of migraine headaches and, in combination with phentermine, for weight loss. Topamac has high bioavailability and low binding to serum proteins. Salivary Topamac levels correlate well with plasma/serum concentrations, making saliva a viable specimen for TDM. Approximately 50% of the absorbed dose is metabolized by the liver. Inhibitors and inducers of liver drug metabolism can significantly alter the serum half-life of Topamac in adults from 20–30 h to 12 h. Children typically clear Topamac faster than adults.
Other names for this medication:
Topiramate,
Topamax,
Epitomax,
Letop,
Neutop,
Piramax,
Talopam,
Topamac,
Topictal,
Topigen,
Topilex,
Topimax,
Topina,
Topiramato,
Topirol,
Toplep,
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