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Topigen (Topiramate)

Topigen is a medication that has been available for a long time to treat migraines and seizures. Based on new research findings, Topigen is now being used “off-label,” or outside of its currently approved indications, to treat alcohol dependence. Specific circumstances, which your physician will discuss with you, may make this medication the first-choice treatment option. Exactly how Topigen works in alcohol dependence is not known, but it is thought to reduce alcohol’s pleasurable effects and so helps people to abstain from alcohol.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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the phosphorylation of neosynthesized UBF proteins predominated. Once this aggregated functional network is constructed, we use again our method to compare it with the structural connectivity to identify particular brain regions that differ in both modalities (anatomical and functional).

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We show that one can maintain the stable steady state of the laser output for an arbitrarily large pump rate by taking advantage of a tracking procedure. Relationship between the tumor necrosis factor receptor II (TNF-RII) gene polymorphism and sTNF-RII plasma levels in healthy controls and in rheumatoid arthritis. These data were extended by performing allogeneic cardiac transplants into ICAM or LFA recipients treated with a 5-day course of anti-CD45RB. Acute pulmonary hemodynamic effects of intravenous copper sulfate: role of alpha-adrenergic system. This was achieved by an enzymatic stripping method (trypsin-EDTA incubation plus gentle scraping) to selectively harvest transitional cells from rat bladders, and the use of the alkaline Comet assay to detect DNA strand breaks, alkaline labile sites, and DNA-protein crosslinks.

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However, some studies have suggested that patients who achieve complete cytogenetic disease remission may not derive an additional prognostic benefit from achieving a major molecular response. While tillering responses to the R/FR ratio were unaffected by the cultivars, low R/FR ratios reduced grain yield per plant (primarily grain number and secondarily grain weight per plant) particularly in modern cultivars.

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Endocrinological aspects in thymus involution in acute inanition The latter has been found in a few clinical isolates of Enterococcus faecalis, whereas the former appears to account for resistance in most strains.

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A small proportion of patients with metastatic renal cell carcinoma have operable liver metastases, as there is often multiple dissemination within the liver and to other organs. Recently completed cancer genomics projects identified intrinsic subtypes in muscle-invasive bladder cancers. MRI may thus provide a noninvasive measure of hematopoietic status. The techniques and approach of mind-body medicine and group support have repeatedly demonstrated their effectiveness at reducing stress and improving the quality of the education experience. Therefore, the families of LDLT are seen to need special supports, especially those who had siblings.

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On September 24, 2003, Oregon epidemiologists noted an increase in Salmonella enterica serotype Typhimurium isolates tested during September at the Oregon State Public Health Laboratories. The complete sequence of the mitochondrial genome of Longlin pig (Sus Scrofa).

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Cholera toxin also triggered a significant reduction in the G(1) cell-cycle regulatory proteins cyclin D1 and Cdk2 along with an overexpression of cell-cycle inhibitory proteins p21(Cip1) and p27(Kip1). Further research is needed to obtain a more comprehensive understanding of them. The significant effect of study day is interpreted as an effect of circadian time, as opposed to accumulating sleep debt. Once you decide upon your personal definition of what a high quality of life is, set goals accordingly to achieve that objective. The functional result was similar irrespective of whether sphincter inhibition was present or not.

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Epidemiology of severity of temporomandibular disorders in Brazilian women. We sought to investigate whether habitual PA is associated with changes of the electrical action potential duration, as it is represented by the QT duration on a rest ECG, in a population based sample of middle-aged and elderly individuals of Ikaria island.

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Progesterone regulates reproductive behavior by activating intracellular progesterone receptors (PRs). Composition-tunable PdPt bimetallic nanoalloys with sub-2.0 nm islands have been successfully synthesized through a facile aqueous solution approach. Autophagy is a lysosome-mediated catabolic process that allows cells to degrade unwanted cytoplasmic constituents and to recycle nutrients. The treatment of cancer usually involves lethal effect on normal body cells as side effects. Regardless of their competition with respect to reproduction, male Japanese macaques on Yakushima Island maintain affiliative relations, probably to cooperatively defend fertile females from non-troop males.

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To evaluate whether statistical signal detection in spontaneous reporting data can lead to earlier detection of drug safety problems and to assess the additional regulatory work entailed. USE OF AMINAZIN IN THE TREATMENT OF INTRACRANIAL BIRTH INJURY IN NEWBORN INFANTS

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Our experience, which includes the largest number of pediatric patients and the youngest child reported in literature, confirms that CE is a very useful system for the clinical work in suspected small-bowel diseases in infancy. A 16-year-old boy presented with a hard mass in the calvarium of posterior fossa region, fever and confusion.

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EID testing data was gathered from the central testing laboratories and was then complemented by health facility level data extraction which took place using a standardized and validated questionnaire In resource-limited settings, where verbal autopsy (VA) is used as the most expedient method of determining cause of death, it is important to understand how pre-existing concepts of cause of death among VA-informants may influence their VA-responses and the consequential impact on cause of death assessment. The finding that ABCG1 promotes the efflux of cholesterol from cells to large HDL particles also provides powerful circumstantial evidence that cholesteryl ester transfer protein inhibition (which increases HDL size) may enhance, rather than reduce, cholesterol efflux, and thus inhibit the development of atherosclerosis. To evaluate the Paris criteria, the revised diagnostic criteria and the simplified diagnostic scoring system in the diagnosis of primary biliary cirrhosis (PBC)-autoimmune hepatitis (AIH) overlap syndrome in Chinese patients.

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Functional electrical stimulation for chronic heart failure: a meta-analysis. The mortality rate among patients with infective endocarditis, especially associated with the presence of complications or coexisting conditions such as renal failure and the use of combined medical and surgical therapy remains still high. In conclusion, the current study demonstrates that activation of extranuclear ER results in induction of ERK-Akt-CREB-BDNF signaling in the hippocampal CA1 region, which significantly reduces ischemic neuronal injury and preserves cognitive function following GCI. PEEP levels of 5 and 10 cmH2O were applied to patients whose end-expiratory alveolar pressures were documented to be positive when breathing against ambient pressure (the auto-PEEP effect).

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These compounds inhibited acetylcholinesterase activity in a dose-dependent manner, and the IC50 values of compounds 1-4 were 89.0, 16.1, 5.8, and 3.3 microM, respectively. A significant increase in TER and a significant decrease in the flux of dextran suggested that IFN-gamma clearly reduced the permeability of both ions and high molecular weight material through the keratinocyte sheet. Amikacin clearance, reflecting the GFR in neonates, can be predicted by birthweight representing the antenatal state of maturation of the kidney, postnatal age representing postnatal maturation, and co-administration of ibuprofen.

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Three fragments show very different abilities to form nucleosomes when low histone-to-DNA ratios require all fragments to compete for available histones. These courses generate various forms of emotional reactions in students that could take the form of anger, silence, avoidance, and passivity. A monoclonal antibody, designated mAb alpha(CT), was generated against a peptide of the ISP(NAP) alpha-subunit of the naphthalene dioxygenase (NDO) enzyme of Pseudomonas aeruginosa.

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Early conversational discourse abilities following traumatic brain injury: an acute predictive study. Strand-specific hybridization probes were utilized in in situ molecular hybridization specifically to localize replicative form DNA of Aleutian mink disease parvovirus (ADV). Hematuria is the most common symptom in bladder lymphoma, outlet obstruction in prostate lymphoma.

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To gain a deeper understanding on the details of these phenomena, we have measured the interfacial activity and contact angle at water/decane interfaces for three different types of nanoparticles: homogeneous poly(methyl methacrylate) (PMMA), silica functionalized with a capping ligand containing a methacrylate terminal group, and Ag-based Janus colloids with two capping ligands of different hydrophobicity. Numerical results reveal that the beam shape coefficients calculated in this way can adequately describe a zero-order Bessel beam with insignificant difference when compared to other relative time-consuming methods involving numerical integration over the spherical coordinates of the GLMT coordinate system, or quadratures. Examples of use of normalized spectral HRV measures in recent articles from the sleep-relevant research literature are critically reviewed. Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4. Of the thirty-four patients in Group II, three (9 percent) had a positive culture after the course of antibiotics.

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This makes it the ideal device for antenatal clinics and primary healthcare facilities in low-income and middle-income countries. Moreover, it should be pointed that it is the first time to discover in theory that there exists the frequency mixing effect induced by three-wave coherent coupling in the regime of non-resonance for the stimulated Brillouin scattering process, which as a consequence determines the periodic state. To elucidate the possible role of affixin in skeletal muscle, we established stable C2C12 cell line expressing T7-tagged human affixin (C2C12-affixin cells).

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Data of 7695 deliveries during 1985-1992 in four general hospitals neighboring a petrochemical works in Guangzhou were collected. Other properties of the enzyme, including isoelectric point, the effects of metal ions and several chemical reagents on the enzyme activity, pH optimum, and amino acid composition were also examined. In the under-researched population of institutionalized stroke patients, we aimed to explore the prevalence of apathy, its clinical correlates, and the relation to the amount of stimulating activities in the nursing home (NH).

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Influence of serum glucose on glutamate decarboxylase activity in the ventromedial nucleus of rats. To label or not to label: applications of quantitative proteomics in neuroscience research.

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An outcome study of a tobacco-free 90-day inpatient dual-diagnosis treatment programme that uses several evidenced-based treatments in addition to ear acupuncture (acudetox) was undertaken to determine overall treatment effectiveness. Recurrent Natural Killer Cell Lymphoma with Central Nervous System Metastasis Mimicking Cerebellar Infarction. Descriptive results show that elderly immigrants are less likely to reside independently, but the large gap of over 15 per cent is reduced to 5 per cent once economic, cultural, life course, and other factors are considered in the multivariate analysis.

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Using the impact of event scale to evaluate psychological response to being a phenylketonuria gene carrier. We begin with a review of classical methods and early heuristic methods, and then focus on more recent work on the seeding of local alignment. Results showed that speckles must have the correct size and density with respect to the facet size of choice for the strain distribution to be computed and reproducible. Cytoskeletal staining of blebs with NBD- phallacidin, a fluorescent probe specific for F-actin, indicated that loss of the bulk of the F-actin cytoskeleton accompanied the release of the natural constraints on later diffusion observed on blebs. Recent immunologic and microbiologic studies suggest a potential role for staphylococcal and streptococcal toxins (superantigens) in the pathogenesis of KS.

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The results were confirmed by an ELISA-based receptor-binding assay. Thus, 12-proxylhexadecanol has been converted into the versatile fatty acid spin label 14-proxylstearic acid. Molecular cloning and sequence analysis of the catalytic subunit of bovine type 2A protein phosphatase.

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(Nematoda: Diplopeltidae) from the continental slope of New Zealand, with description of three new species and notes on their distribution. We analyzed by swept-source anterior segment optical coherence tomography (SS-ASOCT) the three-dimensional iris morphology in a Caucasian population, and correlated the findings with iris color, iris sectors, subject age, and sex. A TUNEL assay to detect DNA fragmentation confirmed these observations of apoptosis. Four siblings with distal renal tubular acidosis and nephrocalcinosis, neurobehavioral impairment, short stature, and distinctive facial appearance: a possible new autosomal recessive syndrome.

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Body-centered tetragonal B2N2: a novel sp3 bonding boron nitride polymorph. Primary cutaneous plasmacytoma after rejection of a transplanted kidney: case report and review of the literature. Transformation by Rous sarcoma virus induces similar patterns of glycosaminoglycan synthesis in chick embryo skin fibroblasts and vertebral chondroblasts. 22 patients with fibrosing alveolitis, 12 patients with lymphangitic spread of tumour and 5 patients with lymphangioleiomyomatosis of the lung were included. The link between social influence and drug abuse has long been established in humans.

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To test the validity and reliability of a graded response questionnaire to identify patients with GERD. Amine-modified DNA detection probe was covalently immobilized on the shortened multi-walled carbon nanotubes (MWCNTs) via diimide-activated amidation between the carboxyl groups on the CNT surface and amine groups on the detection DNA probes. This was a retrospective case series, based in the paediatric emergency departments of the Changhua Christian Hospital and the Tzu-Chi General Hospital, Taiwan. However, many of these in vivo insulin-like effects can be ascribed to the reversal of defects that are secondary to hyperglycemia.

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To evaluate anatomical and functional prognosis of urgent penetrating keratoplasty in perforated infectious corneal ulcers. Reduction of nitroblue-tetrazolium was also a feature of monocytic differentiation. These findings demonstrate for the first time that apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels. COX-2 mRNA and COX-2 protein is constitutively expressed in the kidney, brain, spinal cord, and ductus deferens, and in the uterus during implantation.

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Experiences of mentoring influences on the personal and professional growth of Hispanic registered nurses. The purpose of this study is to construct lipid-polymer hybrid nanoparticles (LPNs) as nanomedicine for co-encapsulation of DTX and curcumin (CUR). A comparative analysis of crystalline lens rise in 9 eyes with co risperidone withdrawal symptoms pigment dispersion and 78 eyes without dispersion was performed. MMP-2 and -9 presented a similar pattern of expression and activity during estrous cycle. One group of ECM molecules which shows an especially broad cooperativity with cytokines and growth factors are the proteoglycans.

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