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Topirol (Topiramate)

Topirol was first approved in the United States in 1996 for treatment of epilepsy. Topirol has gained additional approvals for treatment of migraine headaches and, in combination with phentermine, for weight loss. Topirol has high bioavailability and low binding to serum proteins. Salivary Topirol levels correlate well with plasma/serum concentrations, making saliva a viable specimen for TDM. Approximately 50% of the absorbed dose is metabolized by the liver. Inhibitors and inducers of liver drug metabolism can significantly alter the serum half-life of Topirol in adults from 20–30 h to 12 h. Children typically clear Topirol faster than adults.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Supramolecular and biomimetic polypseudorotaxane/glycopolymer biohybrids: synthesis, glucose-surfaced nanoparticles, and recognition with lectin. Electron scanning microscopy of the prepared fibers, showed that the coating obtained was highly microporous, having a thickness of approximately 5 microm.

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This reaction was shown to be specific for the interaction of equine infectious anemia virus and T lymphocytes. Medullary thyroid carcinoma with micronodular lung metastases: a case report with an emphasis on the imaging findings. In the treatment of the lumbar disc herniaton (LDH) microdiscectomy constitutes one of the standard procedures. Over the last several years there has been a growing interest in placebo, not only as an inert control in clinical trials, but also in the placebo effect as a group effect as well as a reaction in individual subjects.

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We emphasize the value of early recognition of AKs and hypohidrosis as diagnostic clues to FD, a severe and progressive disorder. The enantioselective Friedel-Crafts addition of a variety of indoles catalyzed by bis(oxazolinyl)pyridine-scandium(III) triflate complexes (Sc(III)-pybox) was accomplished utilizing a series of beta-substituted alpha,beta-unsaturated phosphonates and alpha,beta-unsaturated 2-acyl imidazoles. Consequently, the grafted ionic groups which result in the degradation of polymer backbone was decreased to a small degree.

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Egg production, shell thickness, and other physiological parameters of laying hens affected by T-2 toxin. Silicon nanoparticle photophysics and singlet oxygen generation. Patients affected by this syndrome were compared with both healthy subjects and psychiatric patients, using both self-report and physician-scored psychological measures. The diagnosis of anastomotic leak after gastroesophagostomy with biliary scintigraphy. Hemodialysis-induced P-wave signal-averaged electrocardiogram alterations are indicative of vulnerability to atrial arrhythmias.

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Tumor hypoglycemia: relationship to high molecular weight insulin-like growth factor-II. Tumor-associated carbohydrate antigens (TACAs) are attractive targets for the development of anticancer vaccines.

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Scores on this scale may assist health-care providers in identifying caregivers with less preparedness to provide specific interventions. B-mode ultrasonography was performed in 246 patients with suspected abdominal masses over a seven-year period. Here we assess the suitability of mitochondrial data as a phylogenetic marker in mammal phylogenetics.

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Protein-tyrosine phosphorylation is an important post-translational modification that has a major role in cell signaling by affecting protein-protein interactions and enzymatic activities. The level of expression of TAP1 for each population was investigated using a commercial kit that determines the number of antibody-binding sites per cell.

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The ultrastructure of the arterial supply of the human placenta in early and late pregnancy. Performance of the proposed SMCP method and its comparison with LASSO and MCP approaches are evaluated through simulation studies, which demonstrate that the proposed method is more accurate in selecting associated SNPs.

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Thirty KAs (10 at growth stage, 10 at mature stage, and 10 at involution stage) and 28 SCCs (nine well differentiated-Grade 1 (G1), seven moderately differentiated-Grade 2 (G2), five poorly differentiated-Grade 3 (G3), and seven pseudoadenoid) were investigated. In 1998 and 2002, 95 participants went through a clinical investigation including ultrasound of the artery carotis communis. Quantitation of HBV DNA in human serum using a branched DNA (bDNA) signal amplification assay. High-pressure ventilation for 6 hours using conventional flow patterns produces severe lung injury, irrespective of RR or It.

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The aim of this investigation was to study the effects of microtubule-specific drugs, taxol and colcemid, on the distribution of cell-associated extracellular matrix in dense cultures of fibroblasts. To test two measures of visual cortical function in the first year of life as early markers of functionally significant brain damage in infants born preterm: orientation-reversal visual event-related potentials (OR-VERP) and a behavioural test of cortically controlled visual attention-fixation shifts under competition (FS). These data indicate that brain-derived neurotrophic factor and/or neurotrophin-4 could be target-derived factors involved in sensory trigeminal tooth pulp nerve fiber development, differentiation or regeneration. Risk-benefit analysis of lumbar puncture to evaluate for nontraumatic subarachnoid hemorrhage in adult ED patients.

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The expression of PBF in thyroid cancers compared with normal thyroid, hypothesized before the investigation to be raised in tumors, was the main outcome measure. Aortic graft infections: is there still a role for axillobifemoral reconstruction? The aim of the present study was to investigate the association of Bcl-xl expression and radiosensitivity from murine PCa RM-1 cells. Here we provide an overview of recent structural studies that have advanced our understanding of this vital metabolite and question whether the single turnover proteins act to monitor the level of the essential elements used as substrates.

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ON SECRETORY ORGANS IN THE NONAMPULLAR ENDS OF THE SEMICIRCULAR CANAL IN THE HUMAN LABYRINTH Diagnosis of lung cancer by transbronchial lung biopsy and a comparison between this method with the sputum and bronchial washing cytology in Ramathibodi hospital. Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism. More studies are needed to improve techniques that enhance the healing site of the repair. Transverse taeniamyotomy is a simple procedure, rapidly performed, with minimal morbidity, and is well tolerated even by elderly, poor-risk patients.

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The denervation of the adrenal gland did not prevent the increase in adrenal epinephrine by diazepam treatment. A retrospective review of patient records was conducted at the Marian Drummond Adolescent Unit during late 2009 for the period of September 2006 to July 2009.

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RT-PCR analysis shows that the WDR25 gene is widely expressed in human tissues and the expression levers in heart, muscle, testis, ovary, uterus, and prostate are relatively high. Fab fragments derived from both anti-idiotypic antibodies and monospecific antibodies against purified p32 inhibited protein import into mitochondria. Associations between dopamine and serotonin genes and job satisfaction: preliminary evidence from the Add Health Study.

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Selective associations in one-day-old rats: taste-toxicosis and texture-shock aversion learning. Participation of obstetrics and pediatrics on losses through perinatal and infant mortality (results of a 10-year analysis of both mortalities in a medical district) The morbidity rate was 28 per cent and the operative mortality rate was 1 per cent. The WNT signaling pathway contributes to dectin-1-dependent inhibition of Toll-like receptor-induced inflammatory signature.

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The effectiveness of comprehensive geriatric inpatient assessment and rehabilitation on community-dwelling patients is mild. The oral bioavailability appeared to be limited in both species relative to intravenous administration.

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Determination of carbamate pesticides in reservoir water by hollow fiber-based liquid phase microextraction coupled with high performance liquid chromatography Improving the safety of blood transfusion by using a combination of two screening assays for hepatitis C virus. The repeat length was determined by direct sequencing and short tandem repeat assay of PCR-amplified DNA and Southern blotting of unamplified DNA.

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A 1216-bp cDNA sequence obtained by RACE-PCR from the skin encoded a 308 amino acid secretory protein with homology to mammalian and fish intelectins. On the basis of these findings, the analysis of the Th1/Th2 balance may be useful in predicting severe complications during pregnancy.

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Predictive value of brain-stem auditory evoked potentials in children with post-traumatic coma produced by diffuse brain injury. Endometriosis of sigmoid colon mimicking malignant tumor diagnosed by intraoperative imprint cytology. Ventral root responses on stimulation of the pelvic nerve and somatic nerves

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Hemodynamic alterations (elevated central venous pressure and low cardiac output) likely contribute to the formation of tracheobronchial casts composed of inflammatory debris, mucin, and fibrin. Previous electrophysiologic studies appear to demonstrate the possibility of these neurons being osmoreceptors. Absence of histamine liberating effects of certain polymers studied in vitro, in rat

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Finally, there will be a discussion of what the future may hold in terms of the types of dosimeters and the approaches to personnel monitoring, in particular. For a successful transfection, long time of incubation with gene is essential for normal nonviral vectors such as liposomes or cationic lipid-polymer hybrids, because these vectors depend on endocytosis and membrane fusion to realize transfection.

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Antidromic and orthodromic activation of epileptic neurons in neocortex of awake monkey. Field trial displayed that, under the pesticide-applying condition, there was no statistical difference between the negative plants of T(1Ab)-10 and control cultivar Minghui 63. Our results highlight a new role for Ag presenting activated pDCs in promoting the development of Th17 cells and impacting on antitumor immunity. The majority of patients demonstrated an increase of the latent period of peaks P1, P3 and P5 and of the interpeak intervals P1-P3 and P1-P5.

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The natural history and clinical presentation of cervical spondylotic myelopathy. Their low cytotoxicity, high stability in plasma and, in the case of 11, efficient hydrolysis in the presence of alpha-galactosidase, fulfill preliminary conditions for their use in combination with monoclonal antibody-enzyme conjugates. To assess the adequacy of sex education and to determine the incidence of various difficulties encountered in relationships and sexual contact by young adults who have spina bifida (SB) with and without hydrocephalus (HC) in the Netherlands.

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Due to posttransplant long term immunosuppressive treatment careful evaluation of the recipient is essential, especially detection and elimination of all potential sources of malignancy. Indeed, a number of cyanobacterial genomes show extensive N11P paralogous expansion, such as Nostoc, Prochlorococcus and Cyanothece, which replace the TOMM cluster with lanthionine biosynthetic machinery. Fanconi anemia (FA) is an autosomal recessive human disease characterized by genomic instability and a marked increase in cancer risk. Closed endomedullary nailing or ORIF were performed in five cases, with no bone graft. The diets were used in a controlled study of the effects of fat level and P:S on blood pressure, blood lipids, platelet aggregation, and other variables.

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Stimulation of ureogenesis through alpha 1- and beta-adrenoceptors in juvenile rat hepatocytes. These data provide further evidence that dystrophin is a sarcolemma-associated protein, that it is developmentally regulated, and that it is absent or greatly reduced in quantity in skeletal muscle cultures from patients with DMD. The development of a nursing assessment and symptom management clinic. Electrophysiological studies and vascular imaging suggest an ON-limited infarct with subsequent axonal degeneration and selective neuronal loss similar to that seen in human NAION.

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Immunofluorescence revealed granular deposition of monoclonal immunoglobulin G1-lambda and C3 complement along the glomerular basement membrane. A synchronous double cancer of esophagus and stomach treated with 5-fluorouracil and consecutive low-dose cisplatin The resistance phenotype remained during at least 2.5 months of growth in the absence of TM. Rapid induction of pim-1 expression by prolactin and interleukin-2 in rat Nb2 lymphoma cells.

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The RNCs generated with this approach have been successfully used to obtain 3D cryo-electron microscopic reconstructions of complexes with the signal recognition particle and the translocon. Influence of adrenalectomy on urinary excretion of 5-hydroxyindole acetic acid in the rat.

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Contribution of lymphography to the differential diagnosis of malignant lymphoma Eight articles met the inclusion criteria, three of them were randomized.

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Testicular fine needle aspirations and determination of plasma levels of FSH, LH, T, free T, and PRL. Little is known, however, about the applicability of DES to combat veterans. The finalized criteria were validated in a prospective cohort of coronary care unit patients in whom a PAC was placed for clinical indications.

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This disturbs the inducible recruitment of TATA box-binding protein and RNA polymerase II to the IL-8 promoter. The neurological character of types of rheumatism of long development of the central nervous system in children and adolescents The prognostic value of a blunted heart rate response (BHR) during ECG-gated vasodilator stress SPECT MPI in relation to ventricular function on long-term cardiovascular events is not well established. The high percentage of patients taking drugs that may increase INR or bleeding risk is a reminder that bleeding events are a likely adverse outcome of combining drugs that interact with warfarin. Hydrotubation was performed at laparoscopy and intrauterine perfusion pressure was measured.

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These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity. It also economic importance and further information is essential about the epidemiology of the parasite in Ilam province. This result has important implications for such processes as eukaryotic chemotaxis. The impact of cross-immunity, mutation and stochastic extinction on pathogen diversity. For transformants with constitutively active Sccdc42, polar tip growth of apical cells in the leading hyphae was normal but polar tip growth in side branches was altered, implying different regulation of polarity establishment in the two groups of apical cells.

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Using hospital all-payer billing data, we estimate savings from care improvement efforts among inpatient and emergency department high users in thirteen communities that are candidates for participation in the New Jersey demonstration. We retrospectively analyzed quantitative computed tomography scans that had been made with use of a high-resolution multi-slice scanner with a metal artifact-suppression protocol. The observed enthalpy-entropy compensation effect in C16MeImCl and C16MeImCl-NaCMC systems provided important insight as to how micellization processes are governed by the bulk structural property of the solution with respect to that of the water.

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A suggested mechanism for the inhibition of dental caries by monofluorophosphate. Participants noted some concerns about how genetic counseling outcomes will be measured and evaluated given varying stakeholders and the long-term nature of genetic concerns. IVM may be an option for women from whom only low numbers of oocytes are obtained after gonadotrophin stimulation. Both mice and zebrafish lacking p63 expression fail to develop epithelial appendages and other structures that develop as a result of epithelial-mesenchymal interactions.

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Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators. In addition, 0.05 Gy of ionizing radiation activated ERK1/2 and p38, but did not activate JNK1/2 in cells.

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Techniques for handling cells grown in liquid culture, as well as on substrates such as culture dishes, slide culture chambers or agar, are discussed. In the process of transport, Sec12p itself may migrate to the Golgi apparatus and function in subsequent transport events.

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Many patients experience superimposed exacerbations of pain, lasting from seconds to days. Problems dealing with the epidemiology and diagnosis of toxoplasmosis in obstetric cases Furthermore, co-transfection with a dominant-negative mutant Ha-Ras completely blocked NGF-induced luciferase activity. Profilins, regulators of cytoplasmic actin dynamics, also bind to several nuclear proteins but the significance of these interactions is mostly unclear. Dose-response assessment of naphthalene-induced genotoxicity and glutathione detoxication in human TK6 lymphoblasts.

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We present proof-of-concept experiments demonstrating this concept is transferrable to resin-bound DCC, facilitating the generation and analysis of libraries with greater structural diversity. Behavior of glutamic-acetic and racemic acid transaminase and aldolase during the course of infectious hepatitis The aim of this mini-review is to briefly introduce the reader to the major epigenetic regulators so far identified as being implicated in fibrosis. Cytotoxicity was mediated by cells that were non-adherent to nylon wool, non-phagocytic and resistant to thy-1.2 antiserum plus complement.

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A cross-sectional study was conducted in pregnant Brazilian women who enrolled in the primary health-care system in Sao Jose do Rio Preto, Brazil. Experimental results show that by avoiding high-dimensional sparse matrix computations, SSAP outperforms conventional k-means methods and improves upon the standard Affinity Propagation algorithm.

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The behavioral impairments in Rag2(-/-) mice were paralleled by an elevation in plasma corticosterone after behavioral tests. Understanding the relationship between altered glucocerebrosidase and the development of parkinsonian manifestations will provide insights into the genetics, pathogenesis, and treatment of Parkinson disease.

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StopAdvisor could be implemented easily and made freely available, which would probably improve the success rates astepro 0.15 cost of smokers with low socioeconomic status who are seeking online support. Study of serum pepsinogen fractions in patients with duodenal ulcer A parameter sensitivity methodology in the context of HIV delay equation models. Wine spoilage experiments showed antimicrobial action against D. Given the prevalence and burden of intractable pain, additional therapeutic approaches are desired.

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A few controlled trials show that vasopressin causes a decrease in bleeding but has no effect on survival. Development of postural adjustments 150 mg fluconazole jock itch in sitting position during the first half year of life.

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The presence of cartilage in this type of lesion has not been previously reported. These results indicate that NPY may activate the HPA axis in concert tetracycline hcl 250 mg used engines with CRF probably at hypothalamic and/or pituitary levels. Microelectrode tracks, along with electrolytic lesions placed as tissue markers, reveal that the mechanoreceptor projection zones have higher cytochrome oxidase and lower acetylcholinesterase staining than some neighboring regions.

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Equilibrium polymerization in the Stockmayer fluid as a model of supermolecular self-organization. Identification of a surface antigen on Loa loa microfilariae the recognition of which correlates with the amicrofilaremic state in man. Consumption of milk-protein combined with green tea modulates diet-induced thermogenesis. Use of 2-cyanoacrylic acid surgical glue in the treatment can nortriptyline capsules be opened ric hard of perforating eye injuries

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Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil. Sodium fusidate ameliorates the course of diabetes induced in mice by multiple low doses of streptozotocin. The nodes in the pelvic region were classified into three zones: external iliac/obturator, the acyclovir pregnancy acog clone common iliac and the paraaortic zones. DEVELOPMENT OF THE SENSORY NUCLEI OF THE TRIGEMINAL NERVE AND THEIR CELLULAR STRUCTURE IN MAN. Our in vitro studies suggest that eNOS is a critical mediator of EGF-induced hepatocyte proliferation, potentially via its influence on the induction of early growth response-1 (Egr-1) and phosphorylation of c-Jun--known mediators of cell-cycle progression.

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A compensatory increase in the number of neutrophils and eosinophils in the red pulp of the spleen and lymph nodes was found after the second week. Ammonia scavengers have been used in HE patients, leading to improvements in symptoms. We have further studied the relationships between dentin and enamel crystals using HR-TEM lattice imaging of the DEB. Stimulation of ornithine decarboxylase activity alfural 10 mg prednisone and inhibition of S-adenosyl-L-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone).

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In melitase levofloxacina 750 mg four cases, normalization of SSEP waveforms did not occur until after reimplantation of the intercostal arteries despite full return of EEG waveforms, restoration of lower extremity perfusion, and rewarming of the patient. We have identified a novel regulator of neurite formation and extension, the neurite outgrowth multiadaptor, NOMA-GAP, which belongs to a new family of multiadaptor proteins with RhoGAP activity. The alkylaminomethanesulfonate compounds were synthesized in aqueous solution by reaction of primary or secondary amines with formaldehyde/sodium hydrogensulfite addition compound. In this study, we investigated the role of the C-terminal domain for the activity of PCSK9. Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines.

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Line estimates made at an oblique angle differed significantly from estimates made at other angles. Mean hascovir 800 mg cenapred arterial pressure (MAP) after standing up was recorded in 10 patients in five conditions: normal standing, leg muscle tensing, inspiratory pursed lips breathing, inspiratory sniffing, and a device causing inspiratory obstruction. The availability of an on-site cytopathologist is cost-effective.